Rays vs Guardians Prediction, Picks & Odds — Monday, August 25

Rookie Ian Seymour makes his first career start for the Rays, and our expert MLB predictions expect his start to be a dandy against the struggling Guardians.

Ryan Gilbert - Contributor at Covers.com
Ryan Gilbert • Betting Analyst
Aug 25, 2025 • 11:55 ET • 4 min read

MLB

Match starts: 3 hrs
CLE
60 %
TB
40 %
EXPERT PICK - MONEYLINE
Tampa Bay +100 Tampa Bay +100
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Ian Seymour of the Tampa Bay Rays
Photo By - Imagn Images. Ian Seymour of the Tampa Bay Rays.

The Tampa Bay Rays and rookie Ian Seymour hit the road for the start of a three-game series against the Cleveland Guardians and starter Tanner Bibee.

My Rays vs. Guardians predictions are targeting Tampa Bay to hand Cleveland its sixth consecutive loss. 

Read on for my MLB picks for Monday, August 25.

Rays vs Guardians prediction

Rays vs Guardians best betRays moneyline (+100)

After a strong start to August that got Cleveland up to 61-55, the Cleveland Guardians have lost nine of their last 11 games, including five straight. Their bats have gone cold with five runs or fewer in nine consecutive games and 13 of their previous 14, which two straight shutout losses have magnified.

The Tampa Bay Rays have been streaky as of late, winning three in a row, losing their next four, and now winning their last two contests.

Cleveland starter Tanner Bibee is having the worst season of his young career at 9-9 with a 4.62 ERA and 1.29 WHIP. He's allowed multiple runs in every start since May 27, including 4+ in six straight outings (to be fair, he only allowed 2 and 3 ER in two of those starts).

Rays southpaw Ian Seymour will make his first career start after 12 appearances out of the bullpen. He got beat up by the Yankees in mop-up duty in his last outing, but was stellar as a starter in Durham this season, going 9-3 with a 2.62 ERA and 104 strikeouts in 86 innings.

Given the Guardians’ recent struggles and record vs. LHP (15-22), the Rays are the play as underdogs tonight in Cleveland.

Rays vs Guardians same-game parlay (SGP)

The Guardians have been held to Under 3.5 runs in three of their last four and five of their last nine contests overall. They also failed to score more than two runs in four of the previous five meetings against the Rays.

Junior Caminero has homered in two straight games and is slugging .527 on the season. He'll look to add to his total of 37 homers and 21 doubles tonight in Cleveland.

Rays vs Guardians odds

  • Moneyline: Tampa Bay +130 | Cleveland -155
  • Run line: Tampa Bay +1.5 (-160) | Cleveland -1.5 (+135)
  • Over/Under: Over 8 (-118) | Under 8 (-102)

Rays vs Guardians trend

The Tampa Bay Rays have covered the Run Line in 32 of their last 59 away games (+5.35 Units / 7% ROI). Find more MLB betting trends for Rays vs. Guardians.

How to watch Rays vs Guardians and game info

Location Progressive Field, Cleveland, OH
Date Monday, August 25, 2025
First pitch 6:40 p.m. ET
TV FS1
Rays starting pitcher Shane Baz
(8-10, 5.22 ERA)
Guardians starting pitcher Tanner Bibee
(9-9, 4.62 ERA)

Rays vs Guardians latest injuries

Rays vs Guardians weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Ryan Gilbert - Covers
Betting Analyst

Ryan Gilbert brings the passion and pain of being a Philadelphia sports fan. After graduating from Monmouth University with a finance degree, he now uses his statistical background to find inefficiencies in betting markets. With past stops at NHL.com, NBC Sports, and currently at Covers, Ryan's hot picks blend well with the cold ice of a hockey rink.

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