Memorial Day weekend is in full swing, and I have you covered on the diamond, with 15 MLB games gracing the schedule today!
Headlined by an NLCS rematch between the Los Angeles Dodgers and Milwaukee Brewers, let's dive right into my MLB picks for Sunday, May 24.
MLB moneyline picks for May 24
| Matchup | Pick |
|---|---|
 Piratesvs  Blue Jays |
-144 |
 Raysvs  Yankees |
+122 |
 Twinsvs  Red Sox |
+144 |
 Guardiansvs  Phillies |
-122 |
 Tigersvs  Orioles |
-127 |
 Cardinalsvs  Reds |
+108 |
 Metsvs  Marlins |
+104 |
 Marinersvs  Royals |
+127 |
 Dodgersvs  Brewers |
-163 |
 Astrosvs  Cubs |
-156 |
 White Soxvs  Giants |
-104 |
 Rockiesvs  Diamondbacks |
+170 |
 Nationalsvs  Braves |
+150 |
 A'svs  Padres |
-150 |
 Rangersvs  Angels |
-117 |
Prices courtesy of Polymarket as of 5-24.
Trade on the MLB at Polymarket!
Sign up now using our exclusive Polymarket promo code 'COVERS' (on your mobile app only) and get a $20 trading bonus after you deposit $20 to trade on any other event contracts — including MLB moneylines!
*Eligible locations only
Expert MLB moneyline picks for May 24
Pirates vs Blue Jays: Blue Jays (-144)
Blue Jays win probability: 59%
Toronto is starting to hit a groove as winners of four straight, and Dylan Cease should only add to that momentum as the AL strikeout leader takes the mound.
Pittsburgh’s offense is currently without All-Star right fielder Ryan O’Hearn, making this the perfect opportunity for the Jays to keep rolling.
Rays vs Yankees: Rays (+122)
Rays win probability: 45%
It’s 2026, and the Rays are still doing Rays things, defying everyone’s expectations by boasting the best record in the AL at 34-15.
I’ll take Shane McClanahan over Ryan Weathers, so give me the Rays at plus money.
Twins vs Red Sox: Twins (+144)
Twins win probability: 41%
It’s hard to go on X without seeing some type of Red Sox fan meltdown. Even if Sonny Gray is posting encouraging numbers on the season, I much prefer the Twins’ offense over whatever Boston is running out.
(Why is Jarren Duran still leading off?!)
Guardians vs Phillies: Guardians (-122)
Guardians win probability: 55%
While Andrew Painter has endured some rookie blemishes, Parker Messick is a nice sleeper in the Cy Young odds, dealing with a 167 ERA+ and a K% that sits in the 87th percentile at Baseball Savant.
Give me the Guardians in the City of Brotherly Love.
Tigers vs Orioles: Orioles (-127)
Orioles win probability: 56%
My pre-season World Series pick is looking like an abject disaster right now, as the Tigers are 1–9 over their last 10 contests.
I’d like to think they’ll turn things around when Tarik Skubal, Gleyber Torres, and Kerry Carpenter return, but until further notice, I’m fading Detroit.
Cardinals vs Reds: Cardinals (+108)
Cardinals win probability: 48%
Matthew Liberatore has consistently kept Cincinnati hitters in check throughout his career, holding them to a .176/.236/.392 slash line.
With Brady Singer carrying a bloated 6.26 ERA, I’m backing the Cardinals in this NL Central clash.
Mets vs Marlins: Marlins (+104)
Marlins win probability: 49%
Say what you want about the Marlins, but they continue to play hard under skipper Clayton McCullough.
Miami is also notably better at LoanDepot Park, sporting a 17–15 record at home compared to 7–14 on the highway.
Mariners vs Royals: Royals (+127)
Royals win probability: 44%
Seth Lugo has dominated current Mariners hitters, holding them to a lifetime .564 OPS across 70 at-bats.
Listed as plus money at home, I’ll take a shot on Kansas City against Bryan Woo and Seattle.
Dodgers vs Brewers: Dodgers (-163)
Dodgers win probability: 62%
The last time Yoshinobu Yamamoto faced Milwaukee, the Japanese ace tossed a complete game in Game 2 of the NLCS, surrendering just one run.
With Los Angeles finally fully healthy on offense, expect the defending champs to crush Brandon Sproat inside American Family Field.
Astros vs Cubs: Cubs (-156)
Cubs win probability: 61%
Yordan Alvarez is currently day-to-day, and with Carlos Correa and Jose Altuve already on the IL, I’ll ride with the Cubbies at home while the Astros’ offense is compromised.
White Sox vs Giants: Giants (-104)
Giants win probability: 51%
San Francisco ranks dead last in runs per game, so I like the upstart White Sox to stay hot in the Bay Area.
The way the Giants are going, get ready for an absolute fire sale at the trade deadline.
Rockies vs Diamondbacks: Rockies (+170)
Rockies win probability: 37%
Jose Quintana continues to be an ageless wonder, and the Diamondbacks are batting just .202 against the veteran southpaw.
Meanwhile, Ryne Nelson has failed to reach the sixth inning in seven consecutive starts, so I’m all over the Rockies in this desert duel.
Nationals vs Braves: Nationals (+150)
Nationals win probability: 40%
Both of these offenses are crushing the ball, but it’s the Nationals sporting a league-best 124 wRC+ against lefties that has me backing them against Martin Perez.
Athletics vs Padres: Padres (-150)
Padres win probability: 60%
While the Padres have one of the deepest bullpens in baseball, the A’s kryptonite is their relief staff, ranking 23rd in bullpen ERA.
How good would Mason Miller be going 1-2-3 on his former team?
Rangers vs Angels: Rangers (-117)
Rangers win probability: 54%
The Halos are mired in another disastrous campaign, wasting another year of Mike Trout’s Hall of Fame career. Vibes are an absolute mess in Anaheim, with owner Arte Moreno hearing the latest brunt of Angels fans’ frustration.
Head across the street to Disneyland if you want to see something magical. The Rangers roll on Sunday Night Baseball against Reid Detmers, who carries an ugly 1-5 record and 5.07 ERA into this matchup.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
