The New York Mets are in the thick of the National League wild-card race, and they play the second of a three-game set against the Chicago Cubs at Wrigley Field on Wednesday, September 24.
My top Mets vs. Cubs predictions and MLB picks are calling for another high-scoring game in the Windy City tonight.
Mets vs Cubs prediction
Mets vs Cubs best bet: Over 7 (-120)
Chicago Cubs lefty Matthew Boyd has struggled down the stretch with a 5.77 ERA and 1.33 WHIP across his past eight starts, and his underlying 5.02 xFIP doesn’t instill confidence, either.
Boyd probably has a splash of statistical correction ahead of his .302 BABIP and 64.5% strand rate during the stretch, but I’m not expecting marked improvement after he out-pitched his underlying metrics before this highlighted run.
The Chicago lineup is also positioned to tee off on New York Mets righty Jonah Tong, with the rookie bringing a 5.94 ERA and 1.44 WHIP into just his fifth big-league start.
New York and Chicago combined for 16 runs in Tuesday's series opener, and I’m expecting more offense tonight at Wrigley Field.
Mets vs Cubs same-game parlay (SGP)
The New York bats will stay hot. The season is essentially on the line and, as noted, Boyd has struggled. Additionally, the Chicago bullpen was required for 18 outs in the series opener.
While Cubs first baseman Michael Busch is mired in a mini 2-for-17 slump across his past six games, he’s still sporting a solid .265 batting average against righties for the year. His underlying numbers pop, too, with Busch’s 372 wOBA, 2.58 ISO, and .870 OPS against right-handed arms all high-end marks.
Mets vs Cubs SGP
- Mets moneyline
- Over 7
- Michael Busch Over 0.5 hits
Mets vs Cubs odds
- Moneyline: New York +100) | Chicago -120
- Run line: New York -1.5 (+170) | Chicago +1.5 (-210)
- Over/Under: Over 7 (-120) | Under 7 (+100)
Mets vs Cubs trend
The New York Mets have hit the Over in 24 of their last 41 games (+8.40 Units / 18% ROI). Find more MLB betting trends for Mets vs. Cubs.
How to watch Mets vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Wednesday, September 24, 2025 |
| First pitch | 8:05 p.m. ET |
| TV | ESPN |
| Mets starting pitcher | Jonah Tong (2-2, 5.94 ERA) |
| Cubs starting pitcher | Matthew Boyd (13-8, 3.20 ERA) |
Mets vs Cubs latest injuries
Mets vs Cubs weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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