Dodgers vs Guardians Prediction, Picks & Best Bets for Tonight's MLB Game

Allen's prediction: Tanner Bibee limits the damage enough as he puts together a solid outing against the dangerous Dodgers, surrendering no more than two earned runs.

Quinn Allen - Betting Analyst at Covers.com
Quinn Allen • Betting Analyst
May 27, 2025 • 15:38 ET • 4 min read
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This article contains predictions for an old game!

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Tanner Bibee Cleveland Guardians MLB
Photo By - Imagn Images. Guardians right-hander Tanner Bibee can stifle the Dodgers' bats tonight.

Tanner Bibee is the latest Cleveland Guardians pitcher to get thrown into the Los Angeles Dodgers gauntlet.

However, my Dodgers vs. Guardians predictions expect him to have an easier time than teammate Gavin Williams did.

I break the matchup down further with a full slate of MLB picks for Tuesday, May 27.

Dodgers vs Guardians prediction

My Dodgers vs Guardians best bet: Tanner Bibee Under 2.5 earned runs (+115 at Bet365)

Tanner Bibee has been a very solid starter for the Cleveland Guardians since coming up to the big leagues in 2023. This season, he’s 4-4 with a 3.57 ERA in 10 starts, striking out 43 in 58 innings of work while walking only 18. The righty is consistent week in and week out.

Tonight, he’ll face a tough challenge in the Los Angeles Dodgers, who are elite offensively. However, Bibee has allowed Under 2.5 earned runs in five of his last six outings and just tossed seven scoreless against the high-flying Detroit Tigers last week.

In 23 at-bats, L.A. has compiled a .304 average against Bibee. In one career start versus the defending World Series champions, Bibee held them to two earned runs across five frames. Also, the right-hander is lights out at Progressive Field, compiling a 1.46 ERA in 2025 in four appearances. He’s only surrendered four earned runs in over 24 innings on his home mound.

Bibee will keep the Dodgers at bay in the second game of this series.

Dodgers vs Guardians same-game parlay (SGP)

Tanner Bibee Under 2.5 earned runs

Mookie Betts Over 0.5 hits

Dustin May Over 5.5 strikeouts

Mookie Betts isn’t having the best campaign for the Dodgers to his standards, batting just .258 with eight home runs. But, he’s swinging it better in May with a .267 average, and the veteran has made some noise lately.

Betts has cashed the Over in hits in six of his last seven games, finishing with at least one hit in three straight. As for his history against Bibee, Betts is 1 for 3 lifetime. He’ll keep the hitting streak going tonight.

While Dustin May’s 4.09 ERA isn’t anything to write home about, he is racking up the Ks. The righty has struck out 49 hitters in 50.2 innings of work. He has swing and miss stuff, and it’s been on full display lately. May has cashed the Over in punchouts in back-to-back outings, too.

May struck out eight against the Arizona Diamondbacks last week and then compiled another eight Ks in his start before that versus the Los Angeles Angels. The Guardians are also striking out 7.94 times per contest this season.

Dodgers vs Guardians odds

Dodgers vs Guardians live odds

Dodgers vs Guardians opening odds

  • Moneyline: Los Angeles -125 | Cleveland +105
  • Run line: Los Angeles -1.5 (+130) | Cleveland +1.5 (-155)
  • Over/Under: Over 9 (-110) | Under 9 (-110)

Dodgers vs Guardians trend

The Los Angeles Dodgers have hit the Game Total Over in 19 of their last 31 games (+6.00 Units / 18% ROI). Find more MLB betting trends for Dodgers vs. Guardians.

How to watch Dodgers vs Guardians and game info

Location Progressive Field, Cleveland, OH
Date Tuesday, 5-27-2025
First pitch 6:10 p.m. ET
TV SportsNet LA, CLEG
Dodgers starting pitcher Dustin May
(2-4, 4.09 ERA)
Guardians starting pitcher Tanner Bibee
(4-4, 3.57 ERA)

Dodgers vs Guardians latest injuries

Dodgers vs Guardians weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Quinn Allen - Covers
Betting Analyst

Quinn Allen is an experienced sports journalist from Vancouver, Canada who fell in love with sports by the time he could walk. He proceeded to play high-level baseball and soccer growing up and eventually played college baseball in the United States.

After his career ended, Quinn received his broadcast journalism degree from BCIT and has since written for many sports publications. He's currently a senior editor at ClutchPoints and has published work for numerous betting websites in the past. 

Quinn's favorite team is Chelsea FC and he'd like to watch a match at Stamford Bridge one day. He loves to bet on NBA player props and encourages others to bet responsibly and not chase losses.

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