Who would you guys start?

I'm in a standard scoring league that starts 2 RBs and 3 WRs.  My RBs are Steven Jackson, McGahee, Rice, Donald Brown, and Kevin Smith.  My WRs are Wayne, Percy Harvin, Kevin Walter, and Santonio Holmes.  My lean right now is:

 

RB: Jackson, Brown

WR: Wayne, Harvin, Walter

 

I know I should start McGahee, but I feel like Brown may have really good game.  He continues to get more and more carries; I think he'll get the majority of carries sooner rather than later.  As for sitting Holmes, he's cold right now, so I'm going with Harvin.  What do you guys think?

SD's pass defense is actually 8th in the NFL.

good point