Have to Start 3

This is assuming Ryan Mathews is out this Sunday, need to fill 2 WR and a RB/WR. My players are A. Boldin, H. Ward, Demaryius Thomas, Pierre Garcon, Mike Tolbert, Fred Jackson and Donald Driver. Definitely starting Boldin but not sure about the other two, any thoughts?

Looks like Matthews will definately out. I traded Jahvid Best & Kyle Orton (have Manning) for him before last Sunday's games started

I'm starting Tolbert this week so that's who I'd recommend in in your flex spot. Turner likes to run near the GL so I'd say there's a pretty solid chance he finds the endzone.

For your other WR spot it probably has to be Driver. Bears have been stout against the run but the Lions & Boys both had success through the air. Rodgers will get his yards against anyone and I'd say there's a good chance Driver sees a at least a few balls come his way.
Thomas is a little intriguing but maybe wait another week on him. You never know what Josh Mishandles will do but the way to beat Indy has to be by keeping it on the ground.