San Francisco's Injuries
| Player | POS | Status | Date | Note |
|---|---|---|---|---|
| C. Colby | OG | Questionable - Groin( Sep 18, '25) | Sep 18, '25 | |
| Limited Participation In Practice | ||||
| J. Watkins | WR | Out - Calf( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| K. Juszczyk | FB | Injured - Concussion( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| T. Williams | OT | Injured - Knee( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| C. McCaffrey | RB | Injured - Calf( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| S. Neal | CB | Injured - Concussion( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| N. Bosa | DL | Injured - Rest( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| Y. Gross-Matos | DL | Injured - Knee( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| J. Jennings | WR | Questionable - Ankle( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| B. Purdy | QB | Questionable - Shoulder( Sep 18, '25) | Sep 18, '25 | |
| Limited Participation In Practice | ||||
| S. Burford | OG | Out - Knee( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| J. James | RB | Injured - Finger( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
Indianapolis's Injuries
| Player | POS | Status | Date | Note |
|---|---|---|---|---|
| C. Ward | CB | Undefined - Concussion( Sep 19, '25) | Sep 19, '25 | |
| Full Participation In Practice | ||||
| T. Warren | TE | Undefined - Toe( Sep 19, '25) | Sep 19, '25 | |
| Limited Participation In Practice | ||||
| D. Buckner | DL | Injured - Rest( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| S. Ebukam | DL | Injured - Rest( Sep 18, '25) | Sep 18, '25 | |
| Did Not Participate In Practice | ||||
| G. Stewart | DL | Injured - NIR - Rest( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| J. Bachie | LB | Injured - Quadricep( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| A. Ajiake | LB | Injured - Throat( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| J. Downs | WR | Injured - Ankle( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| T. Goodson | RB | Injured - Elbow( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| L. Latu | DL | Injured - Hamstring( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||
| B. Raimann | OT | Injured - Illness( Sep 18, '25) | Sep 18, '25 | |
| Full Participation In Practice | ||||