League leaders Manchester City will play host in the Manchester derby on Sunday, with second-place Manchester United headed across town.
Can City extend their amazing winning run to 22 matches in all competitions? Or can Manchester United end City's winning ways and turn the town red? Find out in our best Premier League predictions and soccer betting picks for Manchester City vs. Manchester United on Sunday, March 7, with kickoff set for 11:30 a.m. ET.
Manchester City vs Manchester United betting preview
Injuries
Manchester City: No injuries to report.
Manchester United: Paul Pogba (Out), Juan Mata (Out), David de Gea (Out), Phil Jones (Out), Donny van de Beek (Doubtful), Anthony Martial (Doubtful).
Betting trend to know
Manchester City are 11-16 O/U in the Premier League this season.

Premier League sharp money and line movement report
By Patrick EversonShortly before game time, PointsBet USA has Manchester City as -200 chalk, with Manchester United a hefty +575 underdog and draw +325. Manchester City is taking 65 percent of bets and 69 percent of money, while 21 percent of bets and 22 percent of dollars are on Manchester United. The draw is getting 14 percent of tickets and 9 percent of money. Bettors also favor Over 2.5 goals today.
Check out the full line movement for this gameSide pick
At some point, surely, the Citizens' incredible run has to end. However, it's difficult to project that happening right now. We have previously seen Pep Guardiola's sides reach incredible heights, whether it was at Barca, Bayern, or even City's record-breaking Premier League campaign in 2017/18. City's current form is not new to Guardiola's career on the touchline and it doesn't seem likely to end on Sunday.
Despite doing the double over City last season, this Manchester United side is not well equipped to defeat their blue neighbors. Their attack has run dry in recent weeks, while their backline — though they have defended well in this campaign — are not well suited to handle City's array of attacking options. With slow-footed players occupying three of the back four, City should be able to exploit space and continue to create a ton of goal-scoring opportunities, with Manchester United unable to create many on the other end.
PICK: Manchester City (-206)
Over/Under pick
Since they put three past a lowly Newcastle United side on Feb. 21, Manchester United's attack has gone quiet. Three straight 0-0 results trail the Red Devils into the derby and that is trouble against a City side who create an absurd number of chances in every match and last failed to score on Dec. 12. The movement of Raheem Sterling and Phil Foden, in particular, will wreak havoc on the Red Devils' backline.
There is no question as to whether City will score in this one or not — that is an inevitability much like their Premier League crown for 2021. The question is whether Manchester United can respond or not. Barring a moment of Bruno Fernandes magic, we aren't betting on it.
PICK: Under 2.5 (+100)
Team prop pick
Unsurprisingly, no team in the Premier League averages more goals in the first half of matches than City, at 1.2. An early goal has become a staple of City's fantastic run, with the lead enabling them to completely take control, keep possession with incredible patterns of play and create chance after chance.
It should be more of the same in this one, with Manchester City quickly exploiting the lack of pace in Manchester United's defense to take an early lead and control the match from there. Expect the Citizens to go ahead in the first 45 minutes of this one and never look back, as they extend their unbeaten run.
PICK: First Team to Score - Manchester City (-250)
Manchester City vs Manchester United betting card
- Manchester City (-206)
- Under 2.5 (+100)
- First Team to Score - Manchester City (-250)
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