Rams vs Seahawks Predictions - Early Picks & Odds for Thursday Night Football Week 16

While trends don't tell the full story, there are so many leaning in the Rams' favor ahead of this TNF clash with the Seahawks that it'd be foolish to discount them.

Joe Osborne: Senior Betting Analyst at Covers
Joe Osborne • Senior Betting Analyst
Dec 15, 2025 • 14:22 ET • 4 min read
Kyren Williams Los Angeles Rams NFL
Photo By - Imagn Images. Rams RB Kyren Williams (23) celebrates after scoring a touchdown.

An NFC heavyweight showdown takes place on Thursday Night Football with the Los Angeles Rams set to hit the road to take on the Seattle Seahawks.

The top spot in the conference is up for grabs, and my early Rams vs Seahawks predictions expect Los Angeles to continue a pattern that’s seen it dominate Seattle.

Check out my early NFL picks for Thursday, December 18.

Rams vs Seahawks predictions

Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.

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Early TNF spread pick: Rams -1 

-105 at bet365

If you like applying betting trends to your handicapping as I do, it’ll be near impossible not to back the Los Angeles Rams on Thursday. 

First and foremost, the Rams have been an elite bet to close out the regular season in recent years, as they’re on a 17-3 against-the-spread tear in December. This includes being 2-0 ATS in 2025, where they’ve scored a combined 86 points vs. the Cardinals and Lions with over 500 total yards in each game. To say they’re locked in right now would be an understatement.

Then we have the trends specific to this matchup. Los Angeles has covered in 11 of the last 14 games against the Seattle Seahawks, including five straight at Lumen Field. 

And, oh yeah, the Rams are also dominating on the road, where they’ve gone 11-2 ATS in their last 13 games and are a red-hot 17-5 ATS overall since December 1, 2024.

Even if you’re not into trends, I think it’s fair to be a little concerned about the Seahawks after they barely got by Philip Rivers and the Colts as 13-point favorites.

While Seattle is still stacking wins, Sam Darnold has cooled off, and it’s fair to question his confidence and ability in important standalone matchups after he crumbled down the stretch last season.

The Rams have really had his number, going 3-0 against him since the start of last season. They made him look like the Jets version of Sam Darnold a little more than a month ago when they forced four interceptions.

Trends don’t always tell the full story, but when this many align with form, matchup, and quarterback history, they’re hard to ignore. On a short week in Seattle, everything points to the Rams continuing their December dominance.

Early TNF total pick: Under 44 

-110 at bet365

While I have more conviction backing the Rams against the spread, the Under is a bet I’m also comfortable supporting. I go that way for the obvious reasons of two high-level defenses along with Darnold’s struggles in high-profile spots and his recent history vs. this Rams defense.

This is a matchup between teams ranked second and third in points allowed, with each also ranking high in yards per play allowed, third-down defense, red-zone defense, and sacks.

A big takeaway from their game in November, which the Rams won 21-19, is that it was trending toward being much lower scoring as they only had 26 combined points with a few minutes left in the game, before each scored a late touchdown. 

The Seahawks have taken full advantage of some light competition of late, holding the Vikings, Falcons, and Colts to a combined 25 points over their last three games.

While the Rams represent a major step-up in competition, we shouldn’t expect another 40-point game out of them.

Unless this game is decided by short fields or defensive scores, it’s hard to see a clean path to a shootout. The matchup, recent meeting, and defensive metrics all point toward a lower-scoring game script.

Rams vs Seahawks odds

  • Rams vs. Seahawks spread: Seahawks +1
  • Rams vs. Seahawks moneyline: Rams -110, Seahawks -110
  • Rams vs. Seahawks Over/Under: 44

How to watch Rams vs Seahawks

  • Rams vs. Seahawks matchup
  • Date: Thursday, December 18, 2025, 8:15 p.m. ET
  • City: Seattle, WA
  • Venue: Lumen Field
  • TV: Prime Video

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Joe Osborne Senior Betting Analyst Covers.com
Senior Betting Analyst

Joe is an industry veteran who loves the entertainment aspect of the sports betting industry. His opinions are always backed by data and he enjoys digging into the numbers and coming up with interesting nuggets to share with sports bettors.

Joe takes a high-energy and fun approach to covering his favorite sports which include the NFL, MLB, UFC, NBA and NHL, and there’s no bet type he loves more than an NFL six-point teaser. Joe is the host of our daily sports betting program, Before You Bet, while he also leads our weekly UFC show, P4P Picks, and our 'Covers on the Ground' series where he's covered many UFC, NFL and NBA games in person. A monthly highlight for Joe is conducting interviews with UFC legend Georges St-Pierre ahead of every UFC PPV.

Outside of his work at Covers, Joe has appeared on many top media brands including ESPN Radio, Mad Dog Sports Radio, VSIN, TSN, and SportsNet. He always recommends not reading too much into narratives when placing your bets as those factors are already cooked into the lines set by oddsmakers.

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