Early Oregon vs Indiana Predictions, Picks & Odds for CFP Peach Bowl

Douglas Farmer breaks down his early Oregon vs. Indiana predictions ahead of Friday's CFP Peach Bowl.

Douglas Farmer - Betting Analyst at Covers
Douglas Farmer • Betting Analyst
Jan 2, 2026 • 20:53 ET • 4 min read
Indiana Hoosiers quarterback Fernando Mendoza (15) celebrates.
Photo By - Imagn Images. Indiana Hoosiers quarterback Fernando Mendoza (15) celebrates.

Yes, the Indiana Hoosiers are the favorites to win the national championship. FanDuel lists them at +128, then followed by the Oregon Ducks at +320.

The Peach Bowl very well may feature the best two teams remaining in the College Football Playoff.

My Oregon vs. Indiana predictions and college football picks are not about to be bold enough to doubt Curt Cignetti.

Oregon vs Indiana predictions

Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.

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Early Oregon vs Indiana spread pick: Indiana -4.5

-105 at FanDuel

Perhaps the most surprising part of Indiana’s dominance is its defensive front. You are not supposed to be able to find top-tier defensive front-seven players via the transfer portal. There are not enough to go around.

Yet, three of the Indiana Hoosiers’ top four pass rushers started their collegiate careers at Navy, Kent State, and James Madison.

Do not engage with anyone who wants to doubt those players. Indiana has done too much to be doubted anymore.

And against Oregon, they should log a few sacks. Dante Moore is not exactly the most mobile quarterback. The Ducks rank No. 91 in scramble rate this season and 16th from the bottom in scramble effectiveness, per CFB-graphs.com.

The Hoosiers’ defensive front should bother Moore enough to disrupt most of Oregon’s offense, and if the Ducks are not humming, they have little hope of keeping up with Heisman-winner Fernando Mendoza.

Early Oregon vs Indiana total pick: Under 47.5

-110 at FanDuel

Oregon has played in three genuinely big games this season: at Penn State, vs. Indiana, and vs. Texas Tech in the Playoff quarterfinals. Yes, that game against Penn State was big at the time. Massive, even.

In regulation, that contest fell 18.5 points short of its total. The other two also both fell short of their totals, by one point against the Hoosiers and by 27.5 against the Red Raiders.

Indiana has also played three genuinely big games this season: at Oregon, vs. Ohio State in the Big Ten title game, and vs. Alabama in the Playoff quarterfinals.

Obviously, that matchup at Oregon fell below its total. So did the other two.

Their offenses may get the headlines, but both the Hoosiers and the Ducks are more driven by their defenses.

Oregon vs Indiana odds

  • Oregon vs. Indiana spread: Indiana -4.5
  • Oregon vs. Indiana moneyline: Oregon +158, Indiana -192
  • Oregon vs. Indiana Over/Under: 47.5

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Douglas Farmer
Betting Analyst

Douglas Farmer spends his days thinking about college football and his nights thinking about the NBA. His betting habits and coverage follow that same pattern. He covered Notre Dame football for various outlets from 2008 to 2024, most notably spending eight seasons as NBC Sports’ beat writer on the Irish. That was also when his gambling focus took off. Knowing there were veteran beat writers with three decades more experience than he had, Douglas found his niche by best recognizing Notre Dame’s standing in each year’s national landscape, a complex tapestry most easily understood and remembered via betting odds.

In 2021, that interest created a freelance opportunity with Covers, a role that eventually led to Douglas joining the company full-time in 2023. In the fall, Douglas will place five or six dozen bets each week, a disproportionate amount via BetRivers because the operator tends to have lines slightly different than the rest of the market. The same can be said of Circa Sports’ futures markets.

While Douglas is an avid NBA fan and covers the league throughout the year, the vast majority of his bets are on college football, because that is the biggest key to sports betting: Know what you do not know.

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