The Oklahoma State Cowboys head to Autzen Stadium for a Week 2 clash with the Oregon Ducks.
Both teams picked up victories over FCS teams in Week 1, albeit in much different fashions — the Cowboys struggled, while the Ducks rolled.
Read on for my Oklahoma State vs. Oregon predictions and college football picks for Saturday, September 6.
Oklahoma State vs Oregon predictions
Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.
Early Oklahoma State vs Oregon spread pick: Oregon -28.5 (+100)
The Oregon Ducks were firing on all cylinders in a 59-13 drubbing of FCS powerhouse Montana State in the opener.
Considering the Ducks limped out of the gates in 2024 with a 10-point win over Idaho and a three-point win over Boise State — and still went on for an undefeated regular season — Week 1’s dominant showing was an announcement they aren’t going anywhere in 2025.
They scored a touchdown on five of six first-half possessions: Quarterback Dante Moore was on point, the running back stable proved its depth, while Kenyon Sadiq and Dakorien Moore emerged as the next star pass catchers.
Contrast that to the Oklahoma State Cowboys, whose 27-7 victory over UT Martin was far from impressive.
Starting QB Hauss Hejney was lost to a foot injury that will keep him out for the foreseeable future, and backup Zane Flores managed just 6.8 yards per attempt in his stead. The running game also faltered (3.0 yards per attempt), so the Cowboys likely won’t manufacture many points in Eugene.
Oregon won four games by 28+ points last year. This is a squash matchup between one of the country’s top programs and one of its worst, featuring a backup QB.
Early Oklahoma State vs Oregon total pick: Under 58.5 (-105)
Oklahoma State managed just 359 yards against UT Martin in the opener. Hejny looked electric to start the game, averaging 9.6 yards per attempt through the air and 6.8 yards per rush while finding the end zone twice. Flores looked less than optimal in his stead, however, and the offense sputtered for most of the game.
Running back Kalib Hicks was entrusted with 21 carries but mustered just 56 yards (2.7 yards per attempt). Why would we expect much better a week later against an Oregon front featuring A’Mauri Washington and Matayo Uiagalelei?
Dan Lannging opted to take his foot off the gas pedal in easy wins over UCLA (34-13), Michigan State (31-10), Purdue (35-0), and Illinois (38-9) last season. If all goes according to plan, a similar result should happen against an overmatched Cowboys team that cannot compete athletically or in the trenches.
The total is high enough the expectation seems to be for either Oregon to run up the score or for Oklahoma State to have some pushback offensively.
The Ducks didn’t prove to do the former last season, and Oklahoma State is far from proving the latter this season.
Oklahoma State vs Oregon odds
- Oklahoma State vs. Oregon spread: Oregon -28.5
- Oklahoma State vs. Oregon moneyline: Oklahoma State +1600, Oregon -4500
- Oklahoma State vs. Oregon Over/Under: 58.5
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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