What are the top college football games in Week 7, and which side of the moneyline should you play for each of them?
We’ve got you covered with picks for each of the top games of the week, whether you’re looking to throw together parlays, are playing them straight, or are simply curious about the outcome of the top games.
Read on for my moneyline plays and college football picks for Week 7.
Week 7 college football moneyline picks
| Matchup | Pick |
|---|---|
 South Florida vs  North Texas |
-116 |
 Ohio State vs  Illinois |
-690 |
 Alabama vs  Missouri |
-156 |
 Oklahoma vs  Texas |
-113 |
 Indiana vs  Oregon |
-315 |
 Florida vs  Texas A&M |
+220 |
 Georgia vs  Auburn |
-166 |
 Michigan vs  USC |
+112 |
Lines courtesy of FanDuel as of 10-8.
Expert Week 7 CFB moneyline picks
South Florida vs North Texas: South Florida (-116)
The action begins in earnest with a tantalizing matchup between two of the AAC’s top teams. No. 24 South Florida is the far more battle-tested squad and will be able to rely on its tough defensive front seven (11th in stuff rate) on the road. Quarterback Byrum Brown is a star.
Ohio State vs Illinois: Ohio State (-690)
No. 17 Illinois cannot be trusted against quality competition after the Indiana debacle (63-10 loss) earlier this season. No. 1 Ohio State has been a Top 5 unit on both offense (third in success rate) and defense (third in EPA per play), looking like a wagon in 2025.
Alabama vs Missouri: Alabama (-156)
No. 8 Alabama is one of the hottest teams in the country, outscoring opponents 165-49 since the Florida State humbling. No. 14 Missouri is no joke at 5-0, but that’s more of a result of their schedule than anything else.
The Tide have covered the spread in four consecutive games, whereas Missouri is 7-14 straight-up against ranked opponents under Eli Drinkwitz.
Oklahoma vs Texas: Texas (-113)
Either John Mateer won’t play and No. 6 Oklahoma stands little chance of moving the ball consistently against a fearsome Texas defense, or he will play and will be at less than 100% for a difficult matchup.
Texas still needs to find itself offensively, but the defense should show out in a favorable matchup. Texas is 10-6 against ranked opponents since 2023.
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Indiana vs Oregon: Oregon (-315)
No. 3 Oregon gets the nod here as a battle-tested team that will be playing at home. No. 7 Indiana has struggled when facing elite athletes, and there are concerns about how its simplistic RPO scheme will work when there isn’t a talent advantage.
The Hoosiers were uncompetitive when stepping up in class last year, falling 38-15 to Ohio State and 27-17 to Notre Dame.
Florida vs Texas A&M: Florida (+220)
Can Florida do it again? If the offense has truly found itself, then of course.
The Gators averaged 7.0 yards per play against a tough Texas defense last week and can pair that with a stingy defense to make some noise in the back half of the schedule.
Georgia vs Auburn: Georgia (-166)
No. 10 Georgia has won eight straight in this series, so the Bulldogs get the slight edge despite this being a less-than-ideal stylistic matchup. Auburn hasn’t been trustworthy through the air on either side of the ball, and the Bulldogs’ tough defensive front seven (fifth in EPA per rush) should make the difference.
Michigan vs USC: Michigan (+112)
No. 15 Michigan possesses the superior defense, and the offense has been no slouch by averaging at least 7.0 yards per play in three consecutive games. USC is just 4-11 against ranked teams under Lincoln Riley, and the defense is still shaky (72nd in success rate).
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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