Miami (OH) heads to Buffalo for a classic dose of midweek MACtion on Wednesday night. Both teams sit at 5-5, but arrive with issues: the RedHawks have dropped two straight and lost their starting quarterback, while the Bulls have fallen in two of their last three and have covered just once since mid-September.
Still, each sits at 4-2 in conference play—only one game behind first-place Central Michigan—turning this matchup into a de facto MAC title eliminator.
My Miami vs. Buffalo predictions and college football picks explain who will come out on top in another wacky midweek MACtion matchup.
Miami (OH) vs Buffalo prediction
Miami (OH) vs Buffalo best bet: Buffalo moneyline (+100)
This is the type of matchup that midweek MACtion is all about. Two teams playing inconsistent ball, but ones that still have a shot at a conference title with a win.
Both the Miami (OH) RedHawks and the Buffalo Bulls are 5-5 overall with 4-2 conference records.
Miami has dropped two in a row after a 4-0 start in MAC play. Buffalo has lost two of its last three and has been one of the worst bets in college football lately, going 1-7-1 against the spread in its last eight games overall.
The Bulls are 1.5-point home underdogs for this matchup, and despite their ugly ATS record, I not only like them to cover but to win this game outright.
The best unit in this game is the Bulls' defense. Buffalo enters this matchup ranked 21st in the country in defensive success rate, 28th on dropbacks, and 22nd on rushes. They also rank second among MAC teams in opponent yards per play.
That Bulls defense will be a problem for Miami in this one. That’s in large part because the RedHawks will be starting their backup QB Henry Hesson after starter DeQuan Finn suddenly left the program prior to last week’s game against Toledo.
Hesson looked overwhelmed against the Rockets, going a dismal 11-for-38 for 147 yards with no touchdowns and three interceptions.
Buffalo has been burned by explosive plays this season. However, Miami doesn’t look capable of producing those at the moment.
The Bulls' defense gives the RedHawks the horns and leads Buffalo to a win at home on Wednesday night. I don’t hate the Bulls' defense to score a touchdown at +800, but our best bet here is Buffalo on the moneyline.
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Miami (OH) vs Buffalo same-game parlay
While the Buffalo defense will lead the way here, the Bulls will still need something out of the passing game to secure a win here. QB Ta’Quan Roberson has been a little interception-prone the last few weeks, but he's been putting up a bunch of yards.
Roberson has averaged 243.9 passing yards over his last seven games, throwing for at least 208 yards five times over that span. Meanwhile, Miami has allowed 194.7 passing yards per game in conference play.
Roberson’s favorite target has been wideout Victor Snow. Snow has 49 catches for 622 yards and seven touchdowns this season. He also has two rushing touchdowns this season.
Miami (OH) vs Buffalo SGP
- Buffalo moneyline
- Ta'Quan Roberson Over 193.5 passing yards
- Victor Snow anytime TD
Our deep-ball SGP: Brunson bullies Buffalo
Hesson really struggled last week, and the RedHawks will need to rely on running back Jordan Brunson in this one.
Miami (OH) vs Buffalo SGP
- Buffalo moneyline
- Ta'Quan Roberson Over 193.5 passing yards
- Victor Snow anytime TD
- Jordan Brunson Over 59.5 rushing yards
Miami (OH) vs Buffalo game predictions
Miami (OH) vs Buffalo moneyline prediction
I'm betting that Buffalo pulls off the upset as the slight home underdog. The Bulls defense will give Miami's inexperienced QB too many problems and led their team to the win.
Miami (OH) vs Buffalo spread prediction
Buffalo has been a bad bet this season, but this matchup sets up well for the Bulls to bounce back. Hesson couldn't find any rhythm against Toledo and lost that game 24-3 as 5.5-point home underdogs.
Miami (OH) vs Buffalo Over/Under prediction
I'm staying away from the total in this one. Both offenses have been struggling and this is a matchup of solid defenses, but this number of 39.5 feels a little too low, particularly when you consider how these midweek MACtion games can get crazy at times.
Miami (OH) vs Buffalo odds
- Spread: Miami (OH) -1.5 | Buffalo +1.5
- Moneyline: Miami (OH) -118 | Buffalo +100
- Over/Under: Over 39.5 | Under 39.5
Miami (OH) vs Buffalo trend to know
The home team has won and covered the spread in seven straight meetings between these two MAC teams, dating back to 2017. Find more college football betting trends for Miami (OH) vs Buffalo.
How to watch Miami (OH) vs Buffalo
| Location | UB Stadium, Buffalo, NY |
| Date | Wednesday, November 19, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ESPN2 |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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