Heisman Trophy Odds for Week 1: Klubnik, Nussmeier Showdown Will Have Ripple Effect

Texas vs. Ohio State will be must-see TV, but don't sleep on LSU vs. Clemson, which features arguably the two best passers in the college ranks this year. It could go a long way toward deciding this year's Heisman race, as Andrew Caley explains.

Andrew Caley - Senior Betting Analyst at Covers.com
Andrew Caley • Senior Betting Analyst
Aug 30, 2025 • 11:22 ET • 4 min read
LSU Tigers NCAAF Garrett Nussmeier
Photo By - Imagn Images. LSU Tigers quarterback Garrett Nussmeier runs with the ball.

What a way to kick off a college football season. We’ve got a pair of matchups in Week 1 that pit the Top 4 Heisman Trophy odds hopefuls against one another. 

It’s Arch Manning vs. Jeremiah Smith when Texas takes on Ohio State, and then it’s Garrett Nussmeier vs. Cade Klubnik as LSU faces off against Clemson.

So, you know we’re going to see a shakeup in the Heisman Trophy odds after today.

Latest Heisman Trophy odds

Here are the current Heisman Trophy favorites heading into today’s action:

Player Position FanDuel
Texas Arch Manning QB +700
LSU Garrett Nussmeier QB +900
Clemson Cade Klubnik QB +900
Ohio State Jeremiah Smith WR +1100
Penn State Drew Allar QB +1800
Alabama Ty Simpson QB +1800
South Carolina LaNorris Sellers QB +1800
Miami Carson Beck QB +1800

Heisman Trophy odds: Matchups to watch

Texas at Ohio State

Is “duh” too on the nose here? The Arch Manning hype train leaves the station when Texas visits Ohio State in Week 1.

Manning is the current favorite to win the Heisman Trophy at +700. We know he’s an excellent athlete, but we haven't yet seen him play against this level of competition. But, if he’s able to have a good day in Columbus, the hype train will go into overdrive, and it will likely be the last chance you see a number like this.

That said, one of Manning’s biggest challengers for the award will also be in this game in super sophomore wide receiver Jeremaiah Smith.

Smith is a freak. Most agree he would have been the first WR selected in the NFL Draft last year. And would be this year. And next year.

Smith went for 1,315 yards and 15 touchdowns as a true freshman last season. He should be even better this year. The only question is how good will new QB Julian Sayin be? And how much will he feed Smith the ball?

LSU at Clemson

Two of the best quarterbacks in the country do battle in Week 1. Garrett Nussmeier and Cade Klubnik come in with matching +900 odds to win the Heisman Trophy.

Nussmeier is coming off a year where he threw for 4,052 yards with 29 touchdowns and 12 interceptions, while Klubnik put up 3,639 yards with 36 TDs and six picks.

But while their odds to win the Heisman are even, I think the value is just with one of them. And that is Klubnik.

The Clemson QB will have more time in the pocket to move the ball down the field against a suspect defense, while LSU’s signal caller is playing behind a rebuilt offensive line, going against a defensive front loaded with NFL talent.

And moving forward, Klubnik will have a better opportunity to put up video game numbers vs the ACC, compared to the gauntlet LSU must survive in the SEC.

Heisman darkhorse: Jump on the wagon with this Sooner

John Mateer, Oklahoma

This is your last chance to jump on the John Mateer bandwagon. Luckily, the Sooners have a wagon you can jump on.

Mateer and his OC Ben Arbuckle came to Norman from Washington State following a season where he threw for 3,139 yards with 29 touchdowns and seven interceptions while adding another 826 yards and 15 scores on the ground.

He is a true dual-threat QB, and if he can come anywhere close to replicating those numbers with the Sooners this season (who I expect to be in contention for the CFP), he will definitely be in the Heisman conversation come December.

His skills should be on display early and often as Oklahoma opens its season as 36.5-point favorites against visiting Illinois State.

John Mateer’s current Heisman odds: +2500

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Andrew Caley
Senior Betting Analyst

When his dreams of becoming the next Steve Nash died, all Andrew "Taco" Caley wanted to do was write about sports, something he's been doing at Covers for more than a decade. A Journalism School grad from Holland College in Charlottetown, PEI, Andrew previously worked at The Chronicle Herald and Star Metro, but knew in his heart that his future lay in sports. He began at Covers as a news editor and has now done everything under the sun when it comes to content. His work has been seen on TSN, Sportsnet, VSiN, and CBS. These days Andrew's betting expertise is focused on his favorite teams; the Toronto Blue Jays and Toronto Raptors. He's also an avid college football fan and bettor. He can't be friends with you if you don't appreciate a Service Academy Under. The sportsbook where he does the bulk of his betting is bet365 thanks to its numerous prop betting options and competitive odds. His best advice? Find the balance between the numbers and what you see on the playing field. Then find the best price using multiple books. And don’t ask him where the nickname Taco comes from. It's not an interesting story. Seriously.

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