Two undefeated teams will face off in a battle between Top-10 squads as the Purdue Boilermakers host the Iowa State Cyclones this afternoon.
The early-season results suggest these teams should be evenly matched, which is why I’m taking the Cyclones to cover in my Iowa State vs. Purdue predictions and college basketball picks.
Iowa State vs Purdue prediction
Iowa State vs Purdue best bet: Iowa State +6.5 (-110)
A dive into the recent history of these two programs will show that the Purdue Boilermakers have been a potential national title winner, while the Iowa State Cyclones merely exist as a very solid and competitive program.
However, if we focus just on what both teams have done this year, a very different picture appears.
These two teams are both 8-0, and both have looked impressive in their victories. The Boilermakers have won every game by at least seven points, while the Cyclones have only had one game finish with a gap of less than 18 points.
We can also review the analytics, and there’s still little to distinguish these squads. Iowa State ranks in the Top 10 in both offensive and defensive efficiency according to KenPom. And while Purdue ranks just No. 19 in defensive efficiency, it tops the country in its offense rating (129.6).
We don’t need to parse the fine details here: these teams are close to evenly matched. And even if Purdue’s reputation gives it the slightest of edges, it’s not enough to justify any significant spread in this game. With more than six points being offered, I’m taking the Cyclones to cover.
Enjoying Covers content? Add us as a preferred source on your Google account
Iowa State vs Purdue same-game parlay
Both Iowa State and Purdue have been open to playing higher-scoring games this year, as their offenses are both efficient and have the ability to put up plenty of points.
I’m also taking Iowa State forward Joshua Jefferson to hit the Over on his scoring total as he’s averaging 18.4 ppg and has scored 16+ points in six of his last seven games.
Iowa State vs Purdue SGP
- Iowa State +6.5
- Over 153.5
- Joshua Jefferson Over 15.5 points
Our beyond the arc SGP: When in Milan!
· Milan Momcilovic has dished out at least two assists in two of his last three games, and at a generous plus number, he’s a great value add to a parlay in Saturday’s game.
Iowa State vs Purdue SGP
- Iowa State +6.5
- Over 153.5
- Joshua Jefferson Over 15.5 points
- Milan Momcilovic Over 1.5 assists
Iowa State vs Purdue odds
- Spread: Iowa State +6.5 | Purdue -6.5
- Moneyline: Iowa State +200 | Purdue -245
- Over/Under: Over 153.5 | Under 153.5
Iowa State vs Purdue betting trend to know
Iowa State has covered the spread in its last three games. Find more college basketball betting trends for Iowa State vs. Purdue.
How to watch Iowa State vs Purdue
| Location | Mackey Arena, West Lafayette, IN |
| Date | Saturday, December 6, 2025 |
| Tip-off | 12:00 p.m. ET |
| TV | CBS |
Iowa State vs Purdue key injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
