Clemson vs Duke Picks and Predictions: Dance With the Blue Devils in the Pale Moonlight

The Duke Blue Devils have been the superior team to the Clemson Tigers all season long. They should win, but the question is "by how much?" We think they'll cover the lofty 11.5-point spread while also keeping this Under the total in our betting picks.

Last Updated: Jan 25, 2022 8:48 AM ET Read Time: 4 min
Paolo Banchero Duke Blue Devils NCAAB
Photo By - USA TODAY Sports

The Duke Blue Devils will take on a familiar ACC foe in tonight’s matchup against the Clemson Tigers. 

Duke is coming off a 20-point home victory over Syracuse after losing a road game in overtime to Florida State. On the other hand, Clemson is 3-5 in ACC play but is coming off a decisive 75-48 win against Pittsburgh. 

Which team will start a two-game winning streak with tonight’s game? Here are our free college basketball betting picks and predictions for the ACC matchup between the Clemson Tigers vs Duke Blue Devils on Tuesday night.

Clemson vs Duke odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

The Duke Blue Devils have fallen to as low as an 11.5-point favorite after opening up at -12.5. Most books are still carrying -12. The 145.5 total has mostly stayed the same, though some books are offering 144.5.

Use the live odds widget above to track any future line movements right up until tip-off and be sure to check out the full college basketball odds before placing your bets.

Clemson vs Duke predictions

Predictions made on 1/25/2022 at 7:55 a.m. ET.
Click on each prediction to jump to the full analysis.

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Clemson vs Duke game info

Location: Cameron Indoor Stadium, Durham, NC
Date: Tuesday, January 25, 2022
Tip-off: 7:00 p.m. ET

Clemson at Duke betting preview


Clemson: No injuries to report.
Duke: Trevor Keels G (Doubtful).

Find our latest NCAA basketball injury reports.

Betting trend to know

The Blue Devils are 4-0 against the spread in their last 4 home games vs. a team with a losing road record. Find more NCAA betting trends for Clemson vs. Duke.

Clemson vs Duke picks and predictions

Our predictions are compiled from the analysis of the spread and total and are indications of where we are leaning for this game.
Our best bet is the play that we like the most for this game, which we would actually put some of our bankroll behind.

The Duke Blue Devils are currently ranked in the Top 20 in both offensive and defensive efficiency via KenPom

On the defensive end, Duke has held opponents to an effective field goal percentage of 45.3% while limiting foul shots at an extremely high rate. Opponents are only hitting 28.8% of threes and just 46.3% of twos against Duke this season. 

The Blue Devils have struggled to keep teams off the glass, as teams have brought down over 30% of offensive rebounds. However, Clemson really isn’t really dangerous in that department. 

Instead, Clemson is a threat from long range. The Tigers are shooting an effective field goal percentage of 54.1% while hitting 38.4% from deep this season. The Tigers have only earned 27% offensive rebounds but have been able to limit turnovers to 16.9%. 

But while Clemson’s offense is strong, Duke’s is much better. Duke is shooting an effective field goal percentage of 55.8% and turning the ball over just 14.8% of the time. 

If the Tigers want any chance of winning this game, they’ll have to shoot lights out from deep and really clean up the defensive glass. 

However, Duke has done very well defending the three and the Blue Devils have also earned 31% of offensive rebounds. Additionally, they're shooting 36.8% from three and 56.1% from inside the arc. 

I’ll take Duke at home and lay the 11.5. Clemson won’t be able to keep up. 

Prediction: Duke -11.5 (-110)

Clemson’s offense won't be able to do enough in this game. Duke has held opponents to a 45.3% effective field goal percentage while limiting teams to 28.8% from deep and 46.3% from inside the arc. 

The only area that opponents have been able to find success against Duke has been in offensive rebounding, but Clemson is averaging just 27% offensive rebounds on the season. 

It takes two to tango and Clemson won’t be good enough to get hit the over. 

Prediction: Under 145.5 (-110)

Clemson’s usually known for its defense, but the Tigers aren’t earning enough turnovers and are allowing plenty of shot attempts from the foul line this season. 

Clemson is slightly above average, allowing teams to shoot 32.5% from three and 47.4% from two. But slightly above average can’t stop talent at Duke's level. 

Pick: Duke -11.5 (-110)

College basketball parlays

Did you know that if you parlayed our Clemson vs. Duke picks, you could win $26.45 on a $10 bet?

Use our college basketball parlay calculator to create your own parlays and see their potential payouts.

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