Two teams on different trajectories intersect Saturday, when the Indiana Pacers visit the San Antonio Spurs.
The Spurs are on a 4-game win streak and trying to chase down the top seed in the West, while Indy has dropped 15 straight and is firmly entrenched in the battle for the top pick in the 2026 NBA Draft.
While Miami has dominated this head-to-head series, my Pacers vs. Spurs predictions and NBA picks have this one in a more defensive battle, where I will target the total.
Pacers vs Spurs prediction
Pacers vs Spurs best bet: Under 233 points (-110)
The Indiana Pacers are 18.5-point underdogs, but weirdly enough, they still compete. Of their 15 straight losses, just five have been by 20+ points.
Their injury list is long, with Ivica Zubac (rib) and Micah Potter (triceps) out and Pascal Siakam (knee) and Andrew Nembhard (knee) headlining a list of seven players listed as questionable.
The San Antonio Spurs have allowed just 105.3 points over their 4-game win streak, with opponents shooting just 42.9% from the field.
Indy will struggle against one of the NBA's premier defenses, who have cashed the Under in three of its last four.
Pacers vs Spurs same-game parlay
Victor Wembanyama has just a single block in each of the last two games, but he's yet to go three straight without picking up at least two. He's swatted at least three shots in 11 of his last 15 games and has also grabbed 12 boards or more in three of his last four games.
Pacers vs Spurs SGP
- Under 233 points
- Victor Wembanyama Over 2.5 blocks
- Victor Wembanyama Over 11.5 rebounds
Our "from downtown" SGP: Wemby!
Wemby is coming off a 34-point game against the Suns, and he's gone for 26+ in six of the last eight; those two Unders came during this current 4-game win streak.
I've targeted his 3-point prop because he's been around this number for a while. Wembanyama has hit the Over four times in his last eight, but he's missed the Over by a single triple in each of the other four games.
Pacers vs Spurs SGP
- Under 233 points
- Victor Wembanyama Over 2.5 blocks
- Victor Wembanyama Over 11.5 rebounds
- Victor Wembanyama Under 25.5 points
- Victor Wembanyama Over 2.5 made threes
Pacers vs Spurs odds
- Spread: Pacers +17.5 (-110) | Spurs -17.5 (-110)
- Moneyline: Pacers +1000 | Spurs -2000
- Over/Under: Over 233.5 (-110) | Under 233.5 (-110)
Pacers vs Spurs betting trend to know
The Pacers have failed to cover the spread in each of their last eight road games. Find more NBA betting trends for Pacers vs. Spurs.
How to watch Pacers vs Spurs
| Location | Frost Bank Center, San Antonio, TX |
| Date | Saturday, March 21, 2026 |
| Tip-off | 8:00 p.m. ET |
| TV | FDSN-IN, FDSN-SW |
Pacers vs Spurs latest injuries
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