The Kansas City Royals enter Saturday’s matchup against the San Diego Padres riding a four-game winning streak, capped by a 6-5 win in Friday night’s series opener.
For my Royals vs. Padres predictions and best MLB picks for June 21, I’m backing Kansas City to stay hot and clinch the series win.
Royals vs Padres prediction
My Royals vs Padres best bet: Royals moneyline (+140 at BetMGM)
The Kansas City Royals' bats have woken up, plating six runs in three of their last four contests, all victories.
Bobby Witt Jr. and Maikel Garcia have been at the forefront of the Royals' offensive renaissance. Witt has eight hits in his last 23 at-bats (.348), while Garcia is 10-for-24 (.417) over the last week.
K.C. tackles San Diego Padres SP Dylan Cease tonight, and he's far off the form that saw him finish fourth in the Cy Young voting a year ago.
Cease was just tagged for six runs by the Dodgers on June 16, marking the fifth time in his last six starts he's allowed three or more earned runs. Backing him is a bullpen that owns a solid but unspectacular 4.20 xFIP over the last two weeks.
The Royals appear to have a major edge in the pitching department with Noah Cameron getting the call. He's allowed one earned run or fewer in six of his first seven starts in 2025, pitching at least six innings on five occasions.
K.C.'s bullpen owns a respectable 3.80 xFIP over the last 14 days.
Royals vs Padres same-game parlay (SGP)
Royals moneyline
Noah Cameron Under 2.5 earned runs allowed
Maikel Garcia Over 0.5 hits
Bobby Witt Jr. Over 0.5 runs
The Royals should prevail at a nice price with the edge in starting pitching. Cease continues to struggle in 2025, and the lefty Cameron should contain the Padres' 21st-ranked lineup by OPS vs. southpaws.
Garcia's bat is hot, and he brings a .348 road batting average into this tilt.
Witt has crossed the plate in five straight affairs, twice via the home run.
Royals vs Padres odds
Royals vs Padres live odds
Royals vs Padres opening odds
- Moneyline: Kansas City +138 | San Diego -153
- Run line: Kansas City +1.5 | San Diego -1.5
- Over/Under: Over 7 | Under 7
Royals vs Padres trend
The Royals have hit the F5 moneyline in 16 of their last 25 away games (+13.80 Units / 49% ROI). Find more MLB betting trends for Royals vs. Padres.
How to watch Royals vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Saturday, 6-21-2025 |
| First pitch | 7:15 p.m. ET |
| TV | FOX |
| Royals starting pitcher | Noah Cameron (2-2, 1.91 ERA) |
| Padres starting pitcher | Dylan Cease (2-6, 4.69 ERA) |
Royals vs Padres latest injuries
Royals vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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