The Seattle Mariners host the San Diego Padres in the final matchup of this three-game series at T-Mobile Park. MLB odds list Seattle as a -135 favorite, while the total sits at 7.5.
My Padres vs. Mariners prediction targets the total in this interleague contest.
Read on for my MLB picks for Wednesday, August 27.
Padres vs Mariners prediction
Padres vs Mariners best bet: Under 7.5 (+100)
After returning from injury in poor form, San Diego Padres SP Yu Darvish has started to settle in. Over his past five starts, the right-hander is 3-0 with a 3.00 ERA and 0.67 WHIP.
Darvish’s underlying metrics suggest this turnaround is likely to continue. Entering this matchup, he ranks in the 60th percentile in expected ERA (xERA), 77th in expected batting average (xBA), 80th in average exit velocity, and 87th in hard-hit rate.
He has also dominated the Seattle Mariners throughout his career, posting a 7-2 record with a 2.55 ERA and 1.09 WHIP over the past 13 meetings.
Meanwhile, the Mariners hand the ball to right-hander Bryan Woo. Perhaps one of the league’s most underappreciated pitchers, Woo is 11-7 with a 2.94 ERA and 0.94 WHIP through 25 starts.
Like Darvish, Woo’s analytics suggest continued success. This season, he ranks in the top quarter of the league in xERA, xBA, and walk rate.
Also like Darvish, Woo has demonstrated great success against Wednesday’s opponent. In his two career starts against San Diego, he is 2-0 with a 1.98 ERA and 0.59 WHIP.
Padres vs Mariners same-game parlay (SGP)
Woo has recorded at least six strikeouts in seven straight starts. Meanwhile, Darvish has struck out six or more batters in seven of his past 13 games against Seattle.
He also boasts a 9.33 K/9 over his past five starts.
Padres vs Mariners odds
- Moneyline: San Diego +115 | Seattle -127
- Run line: San Diego +1.5 | Seattle -1.5
- Over/Under: Over 7.5 | Under 7.5
Padres vs Mariners trend
There have been seven total runs scored in each of Woo’s two career starts against San Diego. Find more MLB betting trends for Padres vs. Mariners.
How to watch Padres vs Mariners and game info
| Location | T-Mobile Park, Seattle, WA |
| Date | Wednesday, August 27, 2025 |
| First pitch | 4:10 p.m. ET |
| TV | PADRES.tv, RSNW |
| Padres starting pitcher | Yu Darvish (3-3, 5.36 ERA) |
| Mariners starting pitcher | Bryan Woo (11-7, 2.94 ERA) |
Padres vs Mariners latest injuries
Padres vs Mariners weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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