MLB Home Run Predictions Today: Best HR Prop Bets, Picks, Parlay & Odds for Wednesday, September 10

Yordan Alvarez hasn't missed a step since returning to the Astros lineup. He has two home runs against Blue Jays SP Jose Berrios in the past, and Houston's big bopper headlines tonight's best home run props.

Quinn Allen - Betting Analyst at Covers.com
Quinn Allen • Betting Analyst
Sep 10, 2025 • 10:17 ET • 4 min read
Yordan Alvarez Houston Astros MLB
Photo By - Imagn Images. Astros DH Yordan Alvarez swings the bat vs. Toronto.

It’s a full 15-game slate across the big leagues, and we've got our sights set on some dingers!

Our MLB player props analysis and home run picks include Shohei Ohtani, Matt Chapman, and Yordan Alvarez on Wednesday, September 10. 

Best MLB home run props today

  • Dodgers Ohtani (+170)
  • Giants Chapman (+491)
  • Astros Alvarez (+320)
  • 💲 +6601 parlay💲

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HR Prop #1: Shohei Ohtani

+170 at DraftKings

Shohei Ohtani is sitting on the doorstep of 50 bombs, smacking 48 while driving in 91. The Japanese phenom is hitting .345 in September with three homers already, which includes a two-home run game over the weekend against the Baltimore Orioles. 

The Los Angeles Dodgers continue a series with the Colorado Rockies tonight, and Ohtani will be excited for the matchup against Kyle Freeland. Ohtani is 6-for-8 lifetime against him with a pair of long balls. Plus, he’s already gone deep five times this season versus Colorado. 

Ohtani has 12 homers off left-handed pitchers and has left the yard 25 times at Dodger Stadium. 

HR Prop #2: Matt Chapman

+491 at DraftKings

Matt Chapman is having a respectable campaign for the San Francisco Giants, hitting .242 with 21 home runs. He’s enjoyed a torrid start to September, batting .400 with three round-trippers. Chapman just homered on Monday against the Arizona Diamondbacks, and he’s facing them again tonight. 

Eduardo Rodriguez takes the hill for the D-Backs, and Chapman is 7-for-18 lifetime against him with four doubles and a homer. Although he’s cranked just three bombs off lefties, that’s a small sample size of 89 at-bats. 

E-Rod has allowed 21 long balls this year in 25 starts, including 17 to right-handed batters. 

HR Prop #3: Yordan Alvarez

+320 at DraftKings

Yordan Alvarez may have been injured for much of the campaign, but we can’t forget the type of power he possesses. The big Cuban smacked 30+ homers in four straight seasons leading up to 2025, so he’s always a threat to leave the ballpark in a hurry. 

The Houston Astros face Toronto Blue Jays right-hander Jose Berrios tonight, and Alvarez has had some success against him, going 3-for-16 with a pair of home runs. Perhaps not the best average, but he’s shown power versus the righty. 

Alvarez has been destroying opposing arms in September. He’s hitting .516 with two round-trippers, and just went 3-for-5 in Tuesday’s loss to the Jays.

Today’s HR parlay

Shohei Ohtani

Matt Chapman

Yordan Alvarez

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Quinn Allen - Covers
Betting Analyst

Quinn Allen is an experienced sports journalist from Vancouver, Canada who fell in love with sports by the time he could walk. He proceeded to play high-level baseball and soccer growing up and eventually played college baseball in the United States.

After his career ended, Quinn received his broadcast journalism degree from BCIT and has since written for many sports publications including ClutchPoints, Gino Hard, and RG, where he plies his trade as a writer and editor.

Quinn's favorite team is Chelsea FC and he'd like to watch a match at Stamford Bridge one day. He loves to bet on NBA player props and encourages others to bet responsibly and not chase losses.

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