Not only are the Chicago Cubs and Milwaukee Brewers battling for top spot in the National League Central, they’re also sporting the two best records in the Senior Circuit.
Chicago visits Milwaukee at American Family Field to start a three-game set on Monday, July 28, and my top Cubs vs. Brewers predictions and MLB picks are calling for a trio of rising stars to show off in the series opener.
Caesars QuickPick: Our Cubs vs Brewers same-game parlay (SGP)
Jackson Chourio Over 1.5 hits + runs + RBI
Michael Busch Over 1.5 hits + runs + RBI
Jacob Misiorowski 6+ strikeouts
Cubs vs Brewers prediction
My Cubs vs Brewers best bet: Jackson Chourio Over 1.5 hits + runs + RBI (-120 at Caesars)
Cubs vs Brewers best bet analysis
Milwaukee Brewers leadoff man Jackson Chourio is cruising along a 20-game hitting streak with 31 hits, 16 runs, and 17 RBI to the tune of a monster 1.056 OPS.
He’s also been lights out all season against left-handed pitchers with an elite .417 wOBA, .235 ISO, and .980 OPS.
While this is a daunting matchup against Chicago Cubs southpaw Matthew Boyd on the surface, statistical correction looms for the first-year North Sider.
To start, Boyd’s sterling 2.22 ERA is miles below his 3.77 xFIP. Additionally, his 82% strand rate and .270 BABIP are likely unsustainable given his respective 66.4% and .294 marks over the past two seasons.
Pitching on the road has also been slightly tougher for the lefty. Boyd’s ERA, WHIP, and BB/9 are all higher on the highway, while his K/9 is lower.
Cubs vs Brewers same-game parlay analysis
Milwaukee rookie Jacob Misiorowski has been dealing since arriving in the bigs, and he’s struck out six or more batters in five of his past six starts. Innings and pitch counts coming for Misiorowski, but this is a huge game, and he only threw 64 pitches across 3 2/3 frames last time out.
He'll pitch deep enough to hit the number tonight, given his high-end 12.27 K/9 and 35.7 K%.
Turning to the final leg of this same-game parlay, Cubs first baseman Michael Busch is another rising star, and he’s teed off on right-handed pitchers this season to the tune of a .409 wOBA, .274 ISO, and .958 OPS.
Busch is also reeling along a mini 5-for-40 stretch at the dish with an unsustainably low .150 BABIP alongside a solid 45.5% hard-hit rate.
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Cubs vs Brewers odds
Cubs vs Brewers live odds
Cubs vs Brewers opening odds
- Moneyline: Chicago -110 | Milwaukee -110
- Run line: Chicago -1.5 (+158) | Milwaukee +1.5 (-189)
- Over/Under: Over 7.5 (-120) | Under 7.5 (+100)
Odds courtesy of Caesars.
Cubs vs Brewers trend
The Milwaukee Brewers have hit the moneyline in 39 of their last 57 games (+19.10 Units / 25% ROI). Find more MLB betting trends for Cubs vs. Brewers.
How to watch Cubs vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Monday, 7-28-2025 |
| First pitch | 7:40 p.m. ET |
| TV | Marquee, FDSNWI |
| Cubs starting pitcher | Matthew Boyd (11-3, 2.20 ERA) |
| Brewers starting pitcher | Jacob Misiorowski (4-1, 2.45 ERA) |
Cubs vs Brewers latest injuries
Cubs vs Brewers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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