Cubs vs Astros Prediction, Picks & Odds for Tonight’s MLB Game

Parker's prediction: Seiya Suzuki and the Cubs will start the weekend right when they visit Space City.

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst
Jun 27, 2025 • 16:56 ET • 4 min read
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This article contains predictions for an old game!

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Seiya Suzuki MLB Chicago Cubs
Photo By - Imagn Images. Chicago Cubs right fielder Seiya Suzuki (27) celebrates with teammates in the dugout.

A pair of division leaders hit the field at Daikin Park tonight, with the Chicago Cubs and Houston Astros kick-starting an interleague series.

Here are my top Cubs vs. Astros predictions for Game 1 of the tape-measuring weekend matchup, where I see Chicago drawing first blood.

Read more in my MLB picks for Friday, June 27. 

Cubs vs Astros prediction

My Cubs vs Astros best bet: Cubs moneyline (-101 at Pinnacle)

Cubs vs Astros same-game parlay (SGP)

Cubs moneyline

Under 8.5

Seiya Suzuki Over 1.5 hits + runs + RBI

Cubs vs Astros odds

Cubs vs Astros live odds

Cubs vs Astros opening odds

  • Moneyline: Chicago -104 | Houston -106
  • Run line: Chicago +1.5 | Houston -1.5
  • Over/Under: Over 8.5 | Under 8.5

Cubs vs Astros trend

The Cubs have hit the moneyline in 45 of their last 74 games (+9.95 Units / 9% ROI). Find more MLB betting trends for Cubs vs. Astros.

How to watch Cubs vs Astros and game info

Location Daikin Park, Houston, TX
Date Friday, 6-27-2025
First pitch 8:10 p.m. ET
TV MARQ, SCHN
Cubs starting pitcher Cade Horton
(3-1, 3.73 ERA)
Astros starting pitcher Brandon Walter
(0-1, 3.80 ERA)

Cubs vs Astros latest injuries

Cubs vs Astros weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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