The Milwaukee Brewers have star Jacob Misiorowski toeing the rubber vs. the Chicago Cubs ahead of the third tilt in their four-game series on Wednesday, Sept. 2, and are sizable road favorites.
First pitch is scheduled for 7:40 p.m. ET, and my top Brewers vs. Cubs predictions and MLB picks are calling for another masterclass from Misiorowski paving the way for a Milwaukee win tonight.
Who will win Brewers vs Cubs today: Brewers moneyline (60.6%)
For help understanding probabilities, see our odds calculator.
Milwaukee Brewers ace Jacob Misiorowski is the rightful betting favorite in the National League Cy Young odds. In addition to his sterling stat line, he’s also beaten the Chicago Cubs twice this season while holding them to a minuscule .202 wOBA and .422 OPS.
We’re landing a fair number because the Cubbies are an admirable opponent and pace the majors in wOBA while ranking second in xwOBA over the past 14 days.
Still, I don’t have confidence in Chicago lefty David Peterson.
His 2.35 ERA across his past eight starts is miles below his underlying 4.39 xERA and 3.73 xFIP. His unsustainable .266 BABIP and 86.5% strand rate during the run also reinforce the screaming statistical correction ahead.
This Brewers moneyline is in play to 62.3%.
COVERS INTEL: Misiorowski paces qualified starters in xERA, xFIP, and strikeout percentage while holding opposing hitters to the lowest barrel percentage.
Brewers vs Cubs Over/Under pick: Under 8.5 (53.7%)
Even with the highlighted concerns for Peterson, he’s still allowed two runs or fewer in seven of the eight starts during the noted stretch, and the Brewers rank a middling 15th in wOBA against lefties for the campaign.
Additionally, the Brewers have an elite bullpen behind Misiorowski, with Milwaukee relievers ranking third in xERA and fifth in xFIP in the second half.
As a result, I don't anticipate either team scoring enough to push this total Over the number.
Brewers vs Cubs home run prediction: Jackson Chourio (20%)
Brewers outfielder Jackson Chourio sports a .194 ISO against lefties and is rolling along a six-game hitting streak, with three homers, a .481 wOBA, and .370 ISO. With perfect hitting conditions at Wrigley Field tonight, Chourio is trading at a fair price to tee off at the Friendly Confines this evening.
- ML/RL bets: 48-21, +29.38 units
- Over/Under bets: 22-19, +1.74 units
Brewers vs Cubs weather
A 90-degree heat wave and wind blowing out at 10 mph will provide favorable hitting conditions at Wrigley Field tonight.
Brewers vs Cubs odds
- Moneyline: Brewers 60.8% | Cubs 42.6%
- Run line: Brewers -1.5 (50%) | Cubs +1.5 (54.5%)
- Over/Under: Over 8 (54.2%) | Under 8 (54.2%)
Brewers vs Cubs trend
The Milwaukee Brewers have won 12 of their last 18 games (+5.25 Units / 21% ROI). Find more MLB betting trends for Brewers vs. Cubs.
How to watch Brewers vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Wednesday, Sept. 2, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | Brewers.TV, MARQ |
| Brewers starting pitcher | Jacob Misiorowski (14-5, 1.73 ERA) |
| Cubs starting pitcher | David Peterson (7-7, 5.11 ERA) |
Brewers vs Cubs latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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