The Chicago Cubs are rolling at the dish and a home favorite over the Milwaukee Brewers in the second meeting of their pivotal four-game series Tuesday, Sept. 1.
The opening pitch is set for 7:40 p.m. ET, and my top Brewers vs. Cubs predictions and MLB picks call for Chicago making it two in a row in another high-scoring bout at the Friendly Confines tonight.
Who will win Brewers vs Cubs today: Cubs moneyline (54.5%)
For help understanding probabilities, see our odds calculator.
The Chicago Cubs offense is set to tee off again with the Milwaukee Brewers sending lefty Robert Gasser (4.52 xERA on the road) to the hill.
Chicago paces the majors in wOBA and ISO against left-handed pitchers, in addition to ranking No. 1 in the two metrics over the past 30 days while also sitting second in xwOBA.
Cubs starter Matthew Boyd is also coming off a bounce-back start with a single run allowed across six innings against an Arizona Diamondbacks offense ranking third in wOBA against lefties for the campaign, so I’m anticipating him keeping the Brewers off balance enough for the Cubbies to pull away.
The Brewers rank 17th in wOBA against southpaws, after all.
COVERS INTEL: The Chicago Cubs pace the majors in wOBA, xwOBA and ISO while averaging 7.5 runs per game across the past two weeks, and land in the highlighted soft matchup against Gasser.
Brewers vs Cubs Over/Under pick: Over 10.5 (47.6%)
Even with Boyd showing off in a tough matchup last time out, he’s still sporting a confidence-shattering 5.50 xERA while surrendering a mammoth 17.0% blast-contact percentage at home.
So, with the Brewers ranking third in xwOBA with an average of 6.0 runs per game over the past two weeks, the Chicago offense isn’t the only one set to put runs on the board tonight.
The icing on the cake is the weather forecast, which also calls for ideal hitting conditions at Wrigley Field.
Brewers vs Cubs home run prediction: Jackson Chourio (20.5%)
Milwaukee outfielder Jackson Chourio is heating up at the dish with three homers during his active five-game hitting streak, and he sports a rock-solid .198 ISO against lefties.
This should also prove to be a favorable matchup with Boyd allowing 14 of his 15 long flies to right-handed hitters alongside a .196 ISO.
- ML/RL bets: 46-20, +28.58 units
- Over/Under bets: 21-17, +2.79X units
Brewers vs Cubs weather
The forecast calls for hot, humid conditions in the upper 80s, with heat index values pushing past 100 F and 8 mph winds blowing out at Wrigley Field tonight.
Brewers vs Cubs odds
- Moneyline: Brewers 50% | Cubs 54.5%
- Run line: Brewers +1.5 (63.6%) | Cubs -1.5 (40%)
- Over/Under: Over 10.5 (52.4%) | Under 10.5 (52.4%)
Brewers vs Cubs trend
The Chicago Cubs have hit the game total Over in 25 of their last 40 games (+9.85 Units / 23% ROI). Find more MLB betting trends for Brewers vs. Cubs.
How to watch Brewers vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Tuesday, Sept. 1, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | TBS |
| Brewers starting pitcher | Robert Gasser (4-5, 4.59 ERA) |
| Cubs starting pitcher | Matthew Boyd (8-3, 3.99 ERA) |
Brewers vs Cubs latest injuries
Odds are correct at the time of publishing and are subject to change.
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