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#2 9/20 NFL

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Posted: Sep. 20, 2026 - 3:51 PM ET #1

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ARZ +4.5 (-120)

Drew Lock takes over after playing well in relief against New England, but his 10-18 career record as a starter raises concerns.

Arizona looked much more stable offensively in its 26-14 win over the Chargers, producing 393 yards with zero turnovers. Jacoby Brissett threw for 277 yards and earned PFF’s highest Week 1 quarterback grade while continuing the solid play he showed last season.

Arizona also held the Chargers to 290 total yards and 14 points. Seattle still has a strong defensive system, but offseason losses weakened the unit. With Brissett playing efficiently and Seattle turning to Lock, Arizona has the more favorable quarterback situation entering this matchup.

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