Detroit 2nd NFC North0-0

Buffalo 1st AFC East0-0

8:15PM ET 8:15PM ET · Sep 17, 2026

Lions vs Bills Odds

Game Odds

Game Odds Detroit Lions vs. Buffalo Bills
	Spread	Total	Moneyline
Detroit Detroit	+3.0 -110	o52.5 -110	+140
Buffalo Buffalo	-3.0 -105	u52.5 -105	-159

Spread

Game Odds Detroit Lions vs. Buffalo Bills
	DET	BUF
	+3.0 -110	-3.0 -105

Odds Comparison

ALL BOOKS	DET	BUF
DraftKings logo	+3.0 -110	-3.0 -110
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	+3.0 -115	-3.0 -105
Caesars logo	-	-
Fanatics Sportsbook logo	-	-

Total

Game Odds Detroit Lions vs. Buffalo Bills
	OVER	UNDER
	o52.5 -110	u52.5 -105

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o52.5 -110	u52.5 -110
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	o52.5 -115	u52.5 -105
Caesars logo	-	-
Fanatics Sportsbook logo	-	-

Moneyline

Game Odds Detroit Lions vs. Buffalo Bills
	DET	BUF
	+140	-159

Odds Comparison

ALL BOOKS	DET	BUF
DraftKings logo	+136	-162
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	+140	-165
Caesars logo	+134	-159
Fanatics Sportsbook logo	-	-

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//Trends script for picks tab