FOX
Seattle @ San Francisco Picks & Props
SEA vs SF Picks
NFL PicksCheck out all football picks and predictions
Latest headlines Checkout latest headlinesRead more
NFL
10/21/2025
03:39 ET
NFL
10/21/2025
02:50 ET
SEA vs SF Consensus Picks
More Consensus
64% picking San Francisco
Total Picks SEA 160, SF 289
66% picking Seattle vs San Francisco to go Over
Total PicksSEA 67, SF 34
SEA vs SF Props
Player
Prop
Season Avg.
Best Odds
SEA vs SF Trends
Check back shortly to see trends for this matchup
SEA vs SF Top User Picks
More PicksSeattle Team Leaders
| Rank | Leader | L10 | Units |
|---|---|---|---|
| 1 | 100towin | 9-1-0 | +5450 |
| 2 | dredog | 8-2-0 | +4900 |
| 3 | MillerBets54 | 8-1-1 | +4450 |
| 4 | WiNNipeg1973 | 8-1-1 | +4400 |
| 5 | dispnum1 | 8-1-1 | +4400 |
| 6 | ern4jets | 8-1-1 | +4400 |
| 7 | coachsalami | 7-2-1 | +4200 |
| 8 | ashotofjack | 8-0-0 | +4000 |
| 9 | Hercules5656 | 8-1-1 | +3950 |
| 10 | JamesGang | 9-1-0 | +3950 |
| All Seahawks Money Leaders | |||
San Francisco Team Leaders
| Rank | Leader | L10 | Units |
|---|---|---|---|
| 1 | Leonoodle | 10-0-0 | +6000 |
| 2 | ThreeTops | 10-0-0 | +6000 |
| 3 | bigguy69 | 8-2-0 | +4900 |
| 4 | HeCo21 | 8-2-0 | +4530 |
| 5 | bobhay | 8-1-1 | +4450 |
| 6 | loulo13 | 8-2-0 | +4400 |
| 7 | manwithnoname6 | 8-2-0 | +4400 |
| 8 | Mtelkslayer | 8-0-0 | +4000 |
| 9 | jmeans11 | 9-1-0 | +3900 |
| 10 | Bluesky | 8-2-0 | +3900 |
| All 49ers Money Leaders | |||