Wyoming @ Colorado Picks & Props

Colorado comes into this game fresh off a bye week, and that will give the home team a huge advantage over the banged-up and exhausted Cowboys. And regardless of who the quarterback is, the path to victory is as simple as running the ball.

The Buffaloes have had success when running the ball for the most part, with an explosive run rate of over 12%. They picked up 146 yards against Georgia Tech, and I expect we’ll see them commit to it here with the struggles at the quarterback position.

Wyoming has the 90th-ranked offense in terms of EPA/play according to GameOnPaper, after adjusting for opponents faced. The Cowboys managed just 10 points against an Akron team that surrendered 68 to Nebraska and 31 to UAB.  

This game will get away from the Cowboys in the end as fatigue eventually takes its toll.

Neither team has experienced offensive success in 2025, and the defense is the more reliable side of the ball for both squads.

The Cowboys have been sound defensively (27th in EPA per play) and can muddy this game enough to stay within the number.