Lamar Jackson and the Baltimore Ravens begin their season on Sunday afternoon against the Indianapolis Colts, with kick-off scheduled for 1 p.m. ET at Lucas Oil Stadium.
Baltimore heads in as a slim 3.5-point favorite, and my Ravens vs. Colts predictions expect the visitors to cover behind their lethal duo of Jackson and Derrick Henry.
Read more in my NFL picks for Sunday, Sep. 13.
TOP PICK
Ravens vs Colts prediction: Ravens -3.5
The Baltimore Ravens get a tough assignment in Week 1 against the Indianapolis Colts, who have Daniel Jones back from an Achilles tear while also possessing an improved defense.
This number makes sense, though. I do not expect Sunday to be a blowout, but the rushing combo of Lamar Jackson and Derrick Henry will be a handful for the Colts' defensive front.
Baltimore has a new OC and a new head coach, and I believe the Ravens will lean heavily on their QB and running back on the ground.
The Colts should keep things interesting, especially with Jonathan Taylor capable of controlling the game on the ground. But Baltimore simply has more difference-makers on both sides of the ball, and I trust Jackson and Henry to eventually wear Indy down.
Expect one of the Ravens' two offensive superstars to make the difference as Baltimore pulls away enough to cover.
Play up to 50%.
COVERS INTEL: Jackson averaged 5.9 yards per carry on the road last season across seven games. At home, his average sat at just 4.4 YPC. 
Ravens vs Colts combo
Ravens -3.5
Lamar Jackson Over 39.5 rushing yards
Daniel Jones Over 225.5 passing yards
Baltimore's offensive weapons give them the edge in Indianapolis, even if this remains competitive.
Jackson is always dangerous with his legs, and he cleared 30 rushing yards in three of Baltimore's final four road games last season. With Henry demanding attention from Indy's front seven, Lamar should have opportunities to find space.
Jones, meanwhile, averaged 238.5 passing yards last season and cleared 225 in seven of his first 10 games before going down.
Baltimore's pass defense struggled badly in 2025, and with Keenan Allen, Alec Pierce, Josh Downs, and others at his disposal, Jones should have enough opportunities to surpass this modest number.
Ravens vs Colts combo
- Ravens -3.5
- Lamar Jackson 30+ rushing yards
- Daniel Jones Over 225 passing yards
Ravens vs Colts touchdown scorer: Derrick Henry
Henry remains one of Baltimore's highest-usage weapons, especially near the goal line. He scored 16 rushing touchdowns last season, with 10 coming from inside the 20-yard line.
The former Alabama star has also made a habit of balling out from the jump. He's found the end zone in two of the last three seasons in Week 1.
Henry's physical running style makes him extremely difficult to stop in short-yardage situations, and if Baltimore gets into the red zone, expect the veteran to get plenty of opportunities to finish the drive.
Play up to 65%.
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Ravens vs Colts odds
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- Spread: Ravens -3.5 | Colts +3.5
- Over/Under: Over 47.5 (52%) | Under 47.5 (49%)
- Moneyline: Ravens 61% | Colts 40%
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Ravens vs Colts weather
Weather in Indianapolis should have no impact since Lucas Oil Stadium is a dome.
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Ravens vs Colts trend to know
Road team is 4-0 ATS in their last 4 meetings. Find more NFL betting trends for Ravens vs. Colts.
How to watch Ravens vs Colts
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Sunday, Sept. 13, 2026 |
| Kickoff | 1 p.m. ET |
| TV | CBS |
Ravens vs Colts latest injuries
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