It’s rivalry time in Los Angeles as the UCLA Bruins face the USC Trojans at the LA Memorial Coliseum for the regular season finale.
USC’s offense has been clicking on all cylinders, and Lincoln Riley will aim for an exclamation mark finish against a miserable UCLA defense.
See why I’m taking the Trojans’ team total Over with my USC vs. UCLA predictions and college football picks for Saturday, November 29.
UCLA vs USC prediction
UCLA vs USC best bet: USC team total Over 40.5 (-130)
There’s bad, and then there’s the UCLA Bruins defense that's been trotting out to the field over the last month. The Bruins have given up at least 48 points in three of their last four games, with the lone exception coming against a backup quarterback who still averaged 13.7 yards per attempt.
The Bruins can’t defend the rush whatsoever, allowing 210+ rushing yards in three of their last four games while ranking 135th in rushing success rate allowed.
The USC Trojans should have no trouble finding consistent running lanes for King Miller, and the offensive line injuries are mitigated in a matchup with UCLA’s porous defensive front (131st in front seven havoc, 132nd in stuff rate).
Quarterback Jayden Maiava will pick apart a Bruins secondary that has been a strength at points this season but is now without lockdown corner Rodrick Pleasant. Maiava’s strong season has paved the way for the Trojans to rank eighth in EPA per play while averaging a robust 479.2 yards per game and 7.3 yards per play. Look for a strong finish to an impressive year for USC’s offense.
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UCLA vs USC same-game parlay
Nico Iamaleava’s status is uncertain after sitting out the Ohio State game with a concussion and then leaving the Washington game early with neck spasms. The offense has looked lost without him (and with him, at times!), failing to crack 225 total yards in three of its last four games.
Don’t expect the Bruins to contribute to the scoring output in this contest, which should keep the game under the total while allowing USC to grab an early lead with little resistance.
UCLA vs USC SGP
- USC team total Over 40.5
- USC -13.5 1st-half spread
- Under 59.5
Our deep-ball SGP: Maiava Mania
USC’s offense works best when Maiava operates the option read and keeps it for himself when the defensive alignment and reaction calls. UCLA is so bad up front, and so bad against the rush in general, that the openings should appear at some point as Maiava looks for his seventh rushing score of the year.
UCLA vs USC SGP
- USC team total Over 40.5
- USC -13.5 1st-half spread
- Under 59.5
- Jayden Maiava anytime touchdown
UCLA vs USC odds
- Spread: UCLA +21.5 (-106) | USC -21.5 (-114)
- Moneyline: UCLA +1100 | USC -2200
- Over/Under: Over 59.5 (-105) | Under 59.5 (-115)
UCLA vs USC trend to know
USC has cashed their team total Over in five of their last six home games. Find more college football betting trends for UCLA vs USC.
How to watch UCLA vs USC
| Location | Los Angeles Memorial Coliseum, Los Angeles, CA |
| Date | Saturday, November 29, 2025 |
| Kickoff | 4:30 p.m. ET |
| TV | NBC |
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