The North Texas Mean Green have quietly become one of the best teams in the nation, and they’ll be out to solidify that status on Friday night when they visit the Charlotte 49ers.
The 49ers' secondary has been tormented all season long, and my North Texas vs. Charlotte predictions expect Mean Green quarterback Drew Mestemaker to sling a few touchdown passes.
Read on for my college football picks for Friday, October 24.
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North Texas vs Charlotte prediction
North Texas vs Charlotte best bet: Drew Mestemaker Over 2.5 passing TDs (-102)
North Texas Mean Green quarterback Drew Mestemaker is set up perfectly to go Over 2.5 passing touchdowns against a Charlotte 49ers defense that simply can’t stop anyone through the air.
The 49ers have allowed 16 passing TDs and 7.8 yards per attempt, and they rarely generate pressure, averaging just 0.86 sacks per game.
Mestemaker should have a clean pocket on nearly every drop back, completing passes at will behind one of Conference USA’s most efficient offensive lines.
With playmakers like Wyatt Young, Miles Coleman, and Cameron Dorner, North Texas spreads the field and attacks all levels of the defense.
Charlotte’s secondary has been torched for multiple passing scores in five straight games, and Mestemaker should keep that streak alive.
North Texas vs Charlotte same-game parlay
Mestemaker has rushed for at least one touchdown in three consecutive games, so let's add that prop to our SGP.
Young leads the Mean Green with six receiving touchdowns, including three scores in Week 7 against UTSA.
North Texas vs Charlotte SGP
- Drew Mestemaker Over 2.5 passing TDs
- Drew Mestemaker anytime TD
- Wyatt Young anytime TD
Our deep-ball SGP: Wicked North
North Texas has covered the spread in four of its last five games. Charlotte has been held to Under 17 points in four of their previous seven games this season.
North Texas vs Charlotte SGP
- Drew Mestemaker Over 2.5 passing TDs
- Drew Mestemaker anytime TD
- Wyatt Young anytime TD
- Charlotte team total Under 16.5
- North Texas -26.5
North Texas vs Charlotte odds
- Spread: North Texas -27.5 (-110) | Charlotte +27.5 (-110)
- Moneyline: North Texas -5000 | Charlotte +1400
- Over/Under: Over 59.5 (-110) | Under 59.5 (-110)
North Texas vs Charlotte trend to know
Charlotte has only hit the team total Over in one of its last six games (-4.95 Units / -70% ROI). Find more college football betting trends for North Texas vs Charlotte.
How to watch North Texas vs Charlotte
| Location | Jerry Richardson Stadium, Charlotte, NC |
| Date | Friday, October 24, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ESPN2 |
North Texas vs Charlotte latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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