The Indiana Hoosiers have done just about everything that can be asked from them except beating a top-tier opponent. The Oregon Ducks are the best opponent the Hoosiers will face this season. Such an upset would change both the Big Ten title race and the national championship picture.
My Indiana vs. Oregon predictions expect entertainment above all else.
Read on for my college football picks for Saturday, October 11.
Read more on this game with Douglas Farmer's Indiana vs. Oregon picks and predictions.
Our best Indiana vs Oregon SGP for Week 7
Curt Cignetti’s entire ethos can be summed up in his emphasis of scripted drives. There is a reason Indiana has mounted a quality drive on at least one of its first two possessions of all five of its games this season.
Meanwhile, Dan Lanning has pushed his Oregon offense to top the first-half total in all three of the Ducks’ home games this season.
This top-10 Big Ten matchup should get out to an aggressive start.
In 3 outta 5 games, Indiana has opened w/ a quality drive.
— Douglas Farmer (@D_Farmer) October 9, 2025
In all five, Indiana had at least one quality drive on its first two possessions.
Oregon has cleared the first half Over in 3 of 5 games. The two exceptions: the shores of Lake Michigan and at Penn State.
1H O 27.5 https://t.co/6fHP0vieoI pic.twitter.com/KoQALRgIEN
Some of that aggression will come from the Oregon Ducks' ground game, no matter how many headlines are increasingly praising quarterback Dante Moore. Indiana has the No. 2 pass defense in the country in terms of expected points added (EPA) per dropback, but the Ducks will not mind that frustration.
Freshman Dierre Hill Jr. took on the biggest workload two weeks ago at Penn State, taking 10 carries for 82 yards after logging just 16 carries in the first four games.
That emphasis bodes well for Oregon’s running back room as it filters out some of its own frustrations.
Asking Dakorien Moore to catch a touchdown against such a quality passing defense may be a surprise, but he is decisively the Ducks’ best receiver, so if anyone is going to crack that top, it should be the freshman.
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