The struggling Memphis Grizzlies hit the road tonight to face Victor Wembanyama-less San Antonio Spurs at the Frost Bank Center.
While I do expect De’Aaron Fox to step up in the place of his star teammate, my Grizzlies vs Spurs predictions explain why the Under in his points prop holds value for the guard.
Read more in my NBA picks for Tuesday, November 18.
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Grizzlies vs Spurs prediction
Grizzlies vs Spurs best bet: De'Aaron Fox Under 26.5 points (-125)
De'Aaron Fox just made his 2025-26 season debut 10 days ago after recovering from injury. The veteran has played well so far, averaging 22 points and 6.8 assists on 37% shooting from long range across five contests.
With Victor Wembanyama sidelined due to a calf injury, the heavy lifting will be on Fox’s shoulders. However, his total is set at 26.5, and to me, that’s too high considering what he’s shown so far.
The Kentucky product has only cashed the Over in points once so far this season. I have no doubts he’s going to step up and do his part, but he typically puts up anywhere from 21-24 points per night.
Plus, other San Antonio Spurs players are more than capable of contributing more without Wemby, including Devin Vassell and Keldon Johnson.
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Grizzlies vs Spurs same-game parlay
Jaylen Wells is averaging 1.5 made threes of 5.3 attempts per night for a 28.4% clip. He’s not an elite shooter by any means and has cashed the Under in six of his last eight appearances. Wells was 1-for-4 from long range on Saturday.
The Memphis Grizzlies may be sitting at 4-10 and without the controversial Ja Morant, but they did win three out of four meetings with San Antonio last season. While the Grizzlies have lost four in a row, there’s no better time to break out of the skid than against a team they’ve dominated in the past.
With Wemby on the shelf, it presents a clear opportunity for Memphis to win.
Grizzlies vs Spurs SGP
- De'Aaron Fox Under 26.5 points
- Jaylen Wells Under 1.5 threes
- Grizzlies moneyline
Our "from downtown" SGP: Santi steps up
Santi Aldama has cashed the Over in points in three of his last five contests. He also averaged 17.8 PPG across four games against San Antonio last season.
Grizzlies vs Spurs SGP
- De'Aaron Fox Under 26.5 points
- Jaylen Wells Under 1.5 threes
- Grizzlies moneyline
- Santi Aldama Over 13.5 points
Grizzlies vs Spurs odds
- Spread: Grizzlies +6 (-115) | Spurs -6 (-105)
- Moneyline: Grizzlies +190 | Spurs -230
- Over/Under: Over 233 (-110) | Under 233 (-110)
Grizzlies vs Spurs betting trend to know
The San Antonio Spurs have only hit the Game Total Under in 22 of their last 58 games (-17.60 Units / -28% ROI). Find more NBA betting trends for Grizzlies vs. Spurs.
How to watch Grizzlies vs Spurs
| Location | Frost Bank Center, San Antonio, TX |
| Date | Tuesday, November 18, 2025 |
| Tip-off | 8:00 p.m. ET |
| TV | NBC, Peacock |
Grizzlies vs Spurs latest injuries
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