It’s fair to wonder if the Cleveland Cavaliers will ever be healthy enough to build playoff momentum, and tonight they’ve got to deal with an in-form New Orleans Pelicans team.
New Orleans’ rough season is trending up, with a 5-1 mark in the past six games, and my Cavaliers vs. Pelicans predictions expect Dejounte Murray to trouble the Cleveland backcourt here.
Check out my NBA picks for a March 21 matchup with plenty of storylines to monitor, including the status of Donovan Mitchell, who’s listed as questionable.
Cavaliers vs Pelicans prediction
Cavaliers vs Pelicans best bet: Dejounte Murray Over 16.5 points (-125)
The New Orleans Pelicans would surely be much closer to the play-in spots if Dejounte Murray had been available all year. They’re 5-4 in his nine outings since returning from an Achilles injury, and he’s averaging 20.7 ppg this month.
Murray sat out Thursday’s win over the Clippers, but he’s gone past this points prop number in four straight games, headlined by 35 points against the Rockets last week.
Though there are other mouths to feed in the New Orleans offense, look for Murray to be in attack mode here against the Cleveland Cavaliers’ shaky perimeter defense.
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Cavaliers vs Pelicans same-game parlay
The last three meetings between these teams have nailed the Over, and Murray and James Harden are two playmakers who can get us there again tonight.
Murray has jacked up 50 shots across his past three outings, while Harden is averaging 8.0 apg this year and dished nine dimes against the Bulls on Thursday.
Cavaliers vs Pelicans SGP
- Dejounte Murray Over 16.5 points
- James Harden Over 7.5 assists
- Over 236.5
Our "from downtown" SGP: Evan Almighty
Whether or not Donovan Mitchell suits up tonight, the Cavs will rely on Evan Mobley to deliver his best, particularly with Jarrett Allen out.
He’s quietly had a great month, with 21.3 ppg and 10.4 rpg, and he’s racked up 15 assists across his last three contests.
Cavaliers vs Pelicans SGP
- Evan Mobley Over 20.5 points
- Evan Mobley Over 10.5 rebounds
- Evan Mobley Over 2.5 assists
- James Harden Over 7.5 assists
Cavaliers vs Pelicans odds
- Spread: Cleveland -4.5 (-110) | New Orleans +4.5 (-110)
- Moneyline: Cleveland -190 | New Orleans +160
- Over/Under: Over 236.5 (-110) | Under 236.5 (-110)
Cavaliers vs Pelicans betting trend to know
The Over is 21-14 for the Cavs on the road this year. Find more NBA betting trends for Cavaliers vs. Pelicans.
How to watch Cavaliers vs Pelicans
| Location | Smoothie King Center, New Orleans, LA |
| Date | Saturday, March 21, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | FDSN-OH, GCSEN |
Cavaliers vs Pelicans latest injuries
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