The Cleveland Guardians are looking to complete a rare four-game sweep against the Baltimore Orioles this afternoon.
My Orioles vs. Guardians predictions expect Cleveland to do just that in my best MLB picks on Thursday, July 24.
Orioles vs Guardians prediction
My Orioles vs Guardians best bet: Guardians moneyline (-116 at FanDuel)
The Cleveland Guardians went into the All-Star break having won six of their previous seven games. They've picked up right where they left off, winning five of six, including the first three in this series against the Baltimore Orioles. On the flip side, the O’s have lost seven of their last eight.
Cleveland got back over .500 both overall (51-50) and at home (25-24) on Wednesday night, while Baltimore sank to 44-57 (22-32 on the road).
The Guardians have mostly taken care of business when expected, going 16-7 as home favorites and 22-9 against teams with winning percentages below .460.
Finally, Cleveland has the advantage on the mound with Logan Allen (6-8, 4.06 ERA) against Charlie Morton (5-8, 5.58 ERA). In fact, the Guardians beat the Orioles 6-3 when these two faced off on April 15.
Orioles vs Guardians same-game parlay (SGP)
Guardians moneyline
Jose Ramirez 2+ hits+runs+RBI
Jackson Holliday 2+ hits+runs+RBI
Jose Ramirez stayed hot on Wednesday with a double, a run scored, and a run batted in. He's now scored in three straight and in 12 of his last 13.
Jackson Holliday is the one Orioles batter playing well since the break. He’s had 2+ HRR in five straight, including two multi-hit contests.
Orioles vs Guardians odds
Orioles vs Guardians live odds
Orioles vs Guardians opening odds
- Moneyline: Baltimore -105 | Cleveland -115
- Run line: Baltimore +1.5 (-180) | Cleveland -1.5 (+150)
- Over/Under: Over 9 (-110) | Under 9 (-110)
Orioles vs Guardians trend
The Cleveland Guardians are 7-1 in their last eight games. Find more MLB betting trends for Orioles vs. Guardians.
How to watch Orioles vs Guardians and game info
| Location | Progressive Field, Cleveland, OH |
| Date | Thursday, 7-24-2025 |
| First pitch | 1:10 p.m. ET |
| TV | MASN, CLEG |
| Orioles starting pitcher | Charlie Morton (5-8, 5.58 ERA) |
| Guardians starting pitcher | Logan Allen (6-8, 4.06 ERA) |
Orioles vs Guardians latest injuries
Orioles vs Guardians weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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