MLB Home Run Predictions Today: Best HR Prop Bets, Picks, & Odds for Wednesday, Sept. 16

Josh Inglis - Betting Analyst at Covers.com
Josh Inglis • Betting Analyst 13+ years betting experience
Updated: Sep 16, 2026 , 09:49 AM ET • 4 min read

Fernando Tatis Jr. is looking for his third straight dinger at Coors Field, and Alec Burleson has the setting, matchup, and price all on his side for an afternoon homer today.

Photo By - Reuters Connect. San Diego Padres right fielder Fernando Tatis Jr. (23) celebrates his solo home run with third base coach Bob Henley (20) in the first inning against the Colorado Rockies at Coors Field.

It's a full-slate Wednesday with some afternoon action, and the MLB player props and home runs are popping on the projections today.

Alec Burleson will get the afternoon party started with some of the best hitting conditions on the slate, and I'm rolling with Fernando Tatis to run the table and homer in his third straight game at Coors Field. 

These are my favorite MLB home run props for Wednesday, Sept. 16.

  • UPDATE: Added another HR pick + parlay.

MLB home run props for today

For help understanding Polymarket probabilities, see our odds calculator.

Player to hit a HR Chance
Cardinals Alec Burleson 19.2%
Padres Fernando Tatis Jr. 25%
Dodgers Ozzie Albies 13.2%
💲Today's HR combo 162.43x
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Home run prediction: Alec Burleson

The Cardinals offense is circled in my notes, and the lefty bat of Alec Burleson is a buy today for a dinger at 22.2% or better.

They get wind blowing out and 90-degree temperatures, which aren't common for mid-September. That's one check for the bats.

Burleson's biggest edge is the pitching matchup. The Cards get to beat up on Anthony Molina, who is starting now and should get hit hard for 75+ pitches today.

He's allowed 12 runs over 12 innings in his three starts and has a 32% groundball rate, which means a lot of fly balls.

Lefty bats are hitting .323 against Molina over his career, with a homer every 20.25 plate appearances, while Burleson has a .550 slugging rate over his last three series with two dingers. 

  • Time: 1:15 p.m. ET
  • Where to watch: Cardinals.TV, NBCS BA

Home run prediction: Fernando Tatis Jr.

I'm heading to Coors to take Fernando Tatis to go yard, and there is room here with a fair probability of 29.4%. The projections are a little low on him, as he's priced as the third-most probable Padre to go deep, but he has already gone deep in each game of this series and might have his best matchup today.

Mason Adams is the day's biggest pitcher fade. In the second half of the season, he has the 20th-worst barrel rate and fourth-worst HR/FB rate among all MLB starters. He's given up five dingers in 18 innings, with only 14 of those outs coming at Coors — where he has allowed two homers.

He's also a reverse-splits pitcher and gets hit harder by right-handed bats.

Only Pete Crow-Armstrong has more homers than Tatis in the second half, and Tatis is slugging at a Top-10 rate since the break.

  • Time: 8:40 p.m. ET
  • Where to watch: Rockies.TV, Padres.TV
Josh Inglis' 2026 Transparency Record
  • HR picks: 38-136, -10.46 units

Odds are correct at the time of publishing and are subject to change.
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Josh Inglis - Covers
Betting Analyst

Josh Inglis is a rising star in the sports betting content space, specializing in MLB, NHL, and NFL markets. Since joining Covers in 2019, Josh has focused his betting expertise on player props and derivative markets, finding them easier for beating the closing line compared to sides and totals. His engaging analysis and content have been showcased on major networks such as TSN, VSiN, BetMGM Network, and NBC. Josh is a prolific bettor, tracking over 2,500 bets annually and he consistently shares his results through monthly transparency reports. At Covers, he is renowned for his MLB release shows and NHL Puck Props, which are integral parts of the site's live content lineup.

Before his tenure at Covers, Josh spent a decade teaching while pursuing sports media on the side. He has also contributed to live global senior-level broadcasts for the WBSC.

Josh advocates for sports bettors to bet early, emphasizing the importance of securing better numbers by beating the public to the market. He also advises having multiple sportsbook accounts to ensure access to the best possible odds.

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