Yoshinobu Yamamoto is on the bump tonight, so I'm riding with him as part of our Cardinals vs. Dodgers predictions.
The Los Angeles Dodgers are massive 70-cent favorites at Polymarket, and we'll be focused on the run line to squeeze out some extra value as a result.
Let’s dive into my MLB picks for Wednesday, Sept. 2.
Who will win Cardinals vs Dodgers today: Dodgers -1.5 (51%)
For help understanding probabilities, see our odds calculator.
When Yoshinobu Yamamoto is on the mound, it's tough to find an edge elsewhere. Yamamoto allowed just seven earned runs across 32 1/3 innings pitched in August (1.95 ERA), and is in a good spot against the St. Louis Cardinals, a team that owns a .176 average against him.
Yamamoto is having another fantastic season, with opponents rocking just a .213 xBA and .340 xSLG against him this year. He'll silence the bats, and with many questions surrounding who will be on the mound for the Cardinals, I'll give the benefit of the doubt to the Los Angeles Dodgers' offense.
COVERS INTEL: With the lowest walk rate of his career (5.9%), the Cardinals are going to have to earn it tonight. Expect Yamamoto to go deep against the team ranked 22nd in wRC+.
Cardinals vs Dodgers Over/Under pick: Under 7.5 (47%)
The Cardinals have yet to announce their starter, but while I think the Dodgers will do enough to cover, their offense has struggled recently. The Under has covered in four of their last five games, and that trend should continue with Yamamoto on the mound tonight.
St. Louis is also one of the best Under teams in baseball, hitting at a 54.2% clip this season.
Cardinals vs Dodgers home run prediction: Pick (16%)
At this price, Jordan Walker is the best bet on the board tonight. Walker owns the highest xSLG (.486) of his career and has an .821 OPS against righties.
Mistakes may be few and far between from Yamamoto tonight, but if there's one guy in the Cardinals' lineup that will capitalize, it's Walker.
- ML/RL bets: 7-9, -0.99 units
- Over/Under bets: 7-8, -1.55 units
Cardinals vs Dodgers weather
It's a perfect night for baseball in Los Angeles, with temperatures of 79 degrees Fahrenheit accompanying sunny skies.
Cardinals vs Dodgers odds
- Moneyline: Cardinals 31% | Dodgers 70%
- Run line: Cardinals +1.5 (50%) | Dodgers -1.5 (51%)
- Over/Under: Over 7.5 (54%) | Under 7.5 (47%)
Cardinals vs Dodgers trend
The Dodgers are 6-0 in Yamamoto's last six starts vs. NL Central teams. Find more MLB betting trends for Cardinals vs. Dodgers.
How to watch Cardinals vs Dodgers and game info
| Location | Dodger Stadium, Los Angeles, CA |
| Date | Wednesday, Sept. 2, 2026 |
| First pitch | 10:10 p.m. ET |
| TV | Cardinals.TV, SNLA |
| Cardinals starting pitcher | TBD |
| Dodgers starting pitcher | Yoshinobu Yamamoto (12-8, 2.56 ERA) |
Cardinals vs Dodgers latest injuries
Odds are correct at the time of publishing and are subject to change.
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