UFC 321 Virna Jandiroba vs Mackenzie Dern Predictions, Picks & Odds

Howard's prediction: Jandiroba settles the score in Abu Dhabi.

Danny Howard - Contributor at Covers.com
Danny Howard • Betting Analyst
Oct 24, 2025 • 18:21 ET • 4 min read
Virna Jandiroba UFC
Photo By - Imagn Images. Virna Jandiroba (blue gloves) during UFC 314 at Kaseya Center.

Virna Jandiroba lost a narrow decision to Mackenzie Dern in 2020, but she's in line for revenge with the vacant strawweight title on the line in the UFC 321 co-main event.

Dern is currently a -155 favorite in the UFC odds, while Jandiroba is listed as a +135 underdog.

Let's dive into my UFC 321: Jandiroba vs. Dern predictions for Saturday, October 25.

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Jandiroba vs Dern prediction and best bet

Fight analysis
When these two first met five years ago, Mackenzie Dern edged out a competitive fight by keeping it upright and relying on her cleaner striking. That version of Dern was still raw, while Jandiroba was a grinding wrestler who struggled to impose her grappling.

Enough has changed in the last five years that, while this remains a fundamentally similar fight, the outcome of their first fight carries little significance ahead of this championship rematch.

Since their first encounter, Jandiroba has gone 6-1 and enters this bout off a dominant decision win over Yan Xiaonan, where she racked up over 10 minutes of control time and repeatedly threatened submissions. Her wrestling style is designed to stifle and neutralize opponents, and once Jandiroba drags a fight to the mat, she rarely lets the competition slip away.

The problem for Dern is that her wrestling is still a work in progress, whereas Jandiroba is more refined. Dern's striking has improved, but she remains hittable, and her lack of takedown defense often leaves her fighting off her back foot.

Ultimately, Jandiroba’s refined wrestling and improved control game give her the edge in dictating where the fight takes place. If she can chain wrestle and get Dern on the mat, Jandiroba should be able to do enough this time to get a win. 

Best bet analysis
Both fighters are durable, and their paths to victory rely on control and position rather than explosive finishing.

Though these two boast impressive ground and submission skills, they are not finishers. Expect this fight to remain relatively low-key, even as it heads into the championship rounds and beyond.

Virna Jandiroba vs Mackenzie Dern odds

Bet99
Method of Victory Jandiroba Dern
To win outright +135 -155
To win by KO/TKO +1900 +600
To win by decision +285 +235
To win by submission +475 +300
Draw +5000 +5000

Odds as of 10-24.

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Virna Jandiroba vs Mackenzie Dern tale of the tape

Jandiroba   Dern
37 Age 32
5-foot-3 Height 5-foot-4
Strawweight Weight Class Strawweight
64 inches Reach 63 inches
22-3 Record 15-5
1 Wins by KO 0
14 Wins by submission 8

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Danny Howard - Covers.com
Betting Analyst

After a decade of covering all things boxing, from recapping the sport’s biggest fights to sharing behind-the-scenes details of the sweet science, Danny found himself immersed in sports betting, focusing on the sports he knows best. As a boxing and MMA contributor with seasoned experience from growing up around each sport, he can uncover the nuances and intangibles that can make the difference between victory and defeat.

Danny’s work has been mentioned on ESPN and USA Today, and he was a featured guest on The Esportz Network podcast, where he shared his combat sports insights. He is also a published author, with his novel And Stay Down! Boxing’s Worst Comebacks available on Amazon.

Danny is always on the lookout for the best odds and props when it comes to fight night, with Draft Kings and BetMGM being his go-to sites. Danny’s approach to finding value in the theater of the unexpected hinges on the fighters' recent form, especially when considering props.

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