We’re set for the second leg of Tottenham against Atletico Madrid in the Champions League this Wednesday, but with the Spaniards holding a three goal lead, this is surely Mission: Impossible for the hosts.
With Spurs needing to attack, and Atletico able to sit back and counter, my Tottenham vs. Atletico Madrid predictions believe we’re set for goals.
Read on for my free betting picks for March 18.
Tottenham vs Atletico Madrid picks and predictions
My Tottenham vs Atletico Madrid best bet: Both teams to score and Over 2.5 goals (-102 at Sports Interaction)
With Tottenham three goals behind in the tie following a 5-2 defeat in Madrid, it’s going to mean them attacking aggressively from early in the matchup, which should see the game open up and allow goals.
We’ve seen both teams score in all five Tottenham matches under Igor Tudor, with Spurs losing four times, and Over 2.5 goals cashing in 80% of those games.
We’ve seen both teams to score win in 10 of Atletico’s 11 games in the Champions League this season, while Over 2.5 goals has also landed in all but one game.
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Tottenham vs Atletico Madrid same-game parlay (SGP)
Both teams to score
Pape Matar Sarr 1+ shot on target
Julian Alvarez 1+ shot on target
Pape Matar Sarr hasn’t been prolific in front of goal this season but has had a shot on target in his past three Premier League starts. With Tottenham chasing this tie, he should get chances.
We’ve seen Julian Alvarez have a shot on target in 55.2% of his games this season, with 21 in 38 games across La Liga and the Champions League, as well as scoring in the first leg of this matchup.
Tottenham vs Atletico Madrid odds
 Tottenham |
 Atletico Madrid |
|
|---|---|---|
| +150 | Moneyline | +155 |
| +270 | Draw | +270 |
| Over 2.5 (-145) | Total | Under 2.5 (+105) |
Odds courtesy of Sports Interaction.
How to watch Tottenham vs Atletico Madrid
| Location | Tottenham Hotspur Stadium, London, England |
| Date | Wednesday, March 18, 2026 |
| Time | 4:00 p.m. ET |
| TV | Paramount+ |
| Weather | 62F, 8 mph winds, 0% PoP. |
Tottenham vs Atletico Madrid key injuries
Tottenham: Wilson Odobert FWR (Out), Rodrigo Bentancur CM (Out), Lucas Bergvall CM (Out), Ben Davies DEF (Out), Mohammed Kudus FWR (Out), Dejan Kulusevski FWR (Out), James Maddison FWR (Out), Richarlison STR (Out), Destiny Udogie LB (Questionable), Joao Palhinha CM (Questionable), Cristian Romero CB (Questionable), Conor Gallagher CM (Questionable).
Atletico Madrid: Rodrigo Mendoza CM (Out), Pablo Barrios CM (Out), Jan Oblak GK (Questionable).
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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