The Indiana Hoosiers are the No. 2 team in the country, and the UCLA Bruins are on a three-game winning streak. What a time to be alive.
One of those things has to end early on Saturday, and my UCLA vs. Indiana predictions expect the better team to keep rolling with aplomb.
Read on for my college football picks for Saturday, October 25.
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UCLA vs Indiana prediction
UCLA vs Indiana best bet: Indiana team total Over 38.5 (-115)
Do not let this coming focus on the Indiana Hoosiers' offense fool you: The Hoosiers’ defense is wildly underappreciated this season. Their defensive front alone warrants excessive praise, the kind of front that could win a College Football Playoff game.
In fact, its success is part of why betting on Indiana’s offense here makes sense. The Hoosiers’ defense limits opponents’ quality drives, giving them up at the third-best rate in the country. Those quicker possessions simply give Indiana’s offense more chances at scoring.
That is part of why the Hoosiers have cleared their Team Total in five of their last six games, falling short only at Iowa, hardly a worrying misstep. This offense is firing on all cylinders, obviously led by the No. 1 passing offense in the country in terms of expected points added per dropback, per CFB-graphs.com.
The UCLA Bruins' defense has improved immensely in recent weeks under interim head coach Tim Skipper, but their three-game winning streak has oddly featured opponents still chucking the ball nearly as often as possible.
Michigan State threw the ball 6.6% more often than would have been expected by an average team in a given game state; Maryland did so 13.6% more often.
Those are not results of the scores. The measurement factors in those game states. Those are the results of UCLA’s run defense bowing up and opponents seeing more potential success through the air.
Indiana will not see mere possible success. The Hoosiers will see realized success.
UCLA vs Indiana same-game parlay
Even as UCLA’s defense has improved, opponents have thrown the ball against the Bruins in recent weeks. They have not thrown it well, but Michigan State and Maryland threw far more often than should have been expected, even in trailing game states.
Fernando Mendoza will pile up some stats with that approach.
And Indiana should make life miserable for Nico Iamaleava. He will be under pressure much of the afternoon. But the worst idea for UCLA would be trying to run against this Hoosiers’ defensive front.
Let Iamaleava put the ball in the air, no matter what comes of it.
UCLA vs Indiana SGP
- Indiana team total Over 38.5
- Fernando Mendoza Over 269.5 passing yards
- Nico Iamaleava Over 269.5 passing yards
Our deep-ball SGP: Fernando!
Rico Flores missed the start of the season, finishing his recovery from a torn ACL. In his four games back, he has cleared this prop in three of them, catching multiple passes in each game.
As UCLA’s offense finds more wrinkles of effectiveness, Flores is among them.
UCLA vs Indiana SGP
- Indiana team total Over 38.5
- Fernando Mendoza Over 269.5 passing yards
- Nico Iamaleava Over 269.5 passing yards
- Indiana -25.5
- Rico Flores Over 23.5 receiving yards
UCLA vs Indiana odds
- Spread: UCLA +25.5 | Indiana -25.5
- Moneyline: UCLA +1600 Indiana -4500
- Over/Under: Over 52.5 | Under 52.5
UCLA vs Indiana trend to know
Remove season openers, and Indiana is 5-1 against the spread when favored by more than three possessions under Curt Cignetti, all six of those games cashing their Overs. Find more college football betting trends for UCLA vs Indiana.
How to watch UCLA vs Indiana
| Location | Memorial Stadium, Bloomington, IN |
| Date | Saturday, October 25, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | FOX |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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