Saturday brings an intriguing AAC showdown as the South Florida Bulls head to Simmons Bank Liberty Stadium to face the Memphis Tigers.
The Tigers are coming off a tough loss, but my South Florida vs. Memphis predictions has the home team keeping this one competitive.
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South Florida vs Memphis prediction
South Florida vs Memphis best bet: Tigers +5.5 (+100)
The Memphis Tigers have won four straight games against the South Florida Bulls, and are 9-1 ATS in their last 10 head-to-head meetings.
Memphis has also dominated two of three home games this season, including a win over Arkansas.
Defensively, Memphis pressures quarterbacks, limits explosive plays, and defends the run effectively, allowing just 3.5 yards per carry and holding opponents to 35% on third downs.
The Tigers' third-down defensive prowess and 14 takeaways this season can and should prevent a USF side, possibly missing leading wideout Chas Nimrod, from turning its aerial attack into a rout.
Memphis has some uncertainty at quarterback, but A.J. Hill stepped in capably for injured starter Brendon Lewis, completing 13 of 25 passes for 175 yards and a touchdown.
Hill is capable of running the balanced Memphis offense and can put points on the board against a Bulls defense that’s allowed 26 or more points in two of its previous three games.
Memphis is one of the best cover teams in the AAC and can be trusted to stay within the spread.
South Florida vs Memphis same-game parlay
Memphis hasn’t surrendered 32 or more points even once this season, so let's add the Under on a lofty South Florida team total to the SGP.
Three of their previous five contests have gone Over the total, and I expect a Memphis offense that’s scored 38 or more points in four of their seven games to come alive on Saturday.
South Florida vs Memphis SGP
- Tigers +5.5
- South Florida team total Under 31.5
- Over 58.5
South Florida vs Memphis game predictions
South Florida vs Memphis moneyline prediction
I like Memphis to pull off the upset. They’ve won seven of their last nine against USF and nine of their last 10 overall.
South Florida vs Memphis spread prediction
Memphis has covered the spread in nine of its last 10 games. They are also 3-0 at home this season with the better defensive unit.
South Florida vs Memphis Over/Under prediction
They combined for 109 points in 2023. This series has gone Over the game total in three of their previous five meetings, and I will back this trend on Saturday.
South Florida vs Memphis odds
- Spread: South Florida -5.5 (-120) | Memphis +5.5 (+100)
- Moneyline: South Florida -220 | Memphis +185
- Over/Under: Over 58.5 (+100) | Under 58.5 (-120)
South Florida vs Memphis trend to know
The Memphis Tigers are 9-1 ATS in their last 10 games. Find more college football betting trends for South Florida vs Memphis.
How to watch South Florida vs Memphis
| Location | Simmons Bank Liberty Stadium, Memphis, TN |
| Date | Saturday, October 25, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ESPN2 |
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Odds are correct at the time of publishing and are subject to change.
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