The Alabama Crimson Tide have done their best to make everyone think their loss to Florida State was nothing more than an early-season blip.
Since then, Bama has won six games in a row thanks in large part to a passing attack led by Ty Simpson that is looking more and more dangerous each week.
Meanwhile, the pressure is building on Shane Beamer as the South Carolina Gamecocks are sitting at 3-4 entering this week.
My Alabama vs. South Carolina predictions and college football picks break down why the Tide offense will keep rolling in this SEC matchup, on Saturday, Oct. 25.
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Alabama vs South Carolina prediction
Alabama vs South Carolina best bet: Alabama team total Over 29.5 (-110)
I’m not going to sugarcoat it. The Alabama Crimson Tide looked bad in their season-opening loss to the Florida State Seminoles. But that sure feels like a lifetime ago at this point.
Alabama has now won six straight games, which includes wins over rivals Georgia and Tennessee, and Ty Simpson and the Crimson Tide's passing attack have been the catalyst.
Simpson looks like one of the best natural passers in the country and has a trio of terrific receivers at his disposal in Ryan Williams, Germie Bernard, and Isaiah Horton. With that group, he’s thrown for 1,931 yards on an impressive 10.8 yards per attempt with 18 touchdowns compared to just two interceptions.
Not only is Simpson now the co-favorite to win the Heisman Trophy (+330 at FanDuel), but he has Alabama’s offense ranked fifth in the country in EPA per play and 13th in success rate on dropbacks. And it’s hard to see the South Carolina Gamecocks slowing down Simpson and Co. this week.
LaNorris Sellers and the Gamecocks haven’t been able to recapture the magic from their 9-4 season a year ago. A big reason for that is that the defensive line that was able to create so much pressure last season had to replace almost all of its impact players, and that’s showing up in the numbers.
South Carolina enters this game 92nd in defensive success rate, including 114th on dropbacks. That doesn’t bode well against this Bama offense.
Alabama has played five Power Four teams during this six-game winning streak, averaging 31.2 points per game, going for 30-plus points three times. I’m betting they make it four of six this weekend. Roll Tide.
Alabama vs South Carolina same-game parlay
Simpson hasn’t gone over this number in the last two games, but I really like him to here. South Carolina ranks 114th in defensive success rate on dropbacks, and they haven’t really faced a pure passer like Simpson yet this season, with the best probably being Diego Pavia. Simpson will pick this secondary apart and get Over 265.5 passing yards.
One of the guys who will help him do that is Isaiah Horton. Horton has quietly become one of Simpson’s favorite targets in recent weeks and has scored a touchdown in five of Alabama’s last six games. I’m betting he makes it six of seven this weekend. Add a Horton TD to this SGP.
Alabama vs South Carolina SGP
- Alabama Team Total Over 29.5
- Ty Simpson Over 265.5 Passing Yards
- Isaiah Horton TD
Our deep-ball SGP: Overpowered Gamecocks
We're adding LaNorris Sellers to go Over his rushing yards, not necessarily because I think he's going to be effective, but he looks healthy and could be running for his life a bunch against this Alabama defense.
Alabama vs South Carolina SGP
- Alabama Team Total Over 29.5
- Ty Simpson Over 265.5 Passing Yards
- Isaiah Horton TD
- LaNorris Sellers Over 19.5 Rushing Yards
Alabama vs South Carolina odds
- Spread: Alabama -11.5 | South Carolina +11.5
- Moneyline: Alabama -500 | South Carolina +385
- Over/Under: Over 47.5 | Under 47.5
Alabama vs South Carolina trend to know
Alabama has covered the Spread in 9 of its last 13 games for +5.70 Units and a 40% ROI. Find more college football betting trends for Alabama vs South Carolina.
How to watch Alabama vs South Carolina
| Location | Williams-Brice Stadium, Columbia, SC |
| Date | Saturday, October 25, 2025 |
| Kickoff | 3:30 p.m. ET |
| TV | ABC |
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