What a difference a couple of years makes.
The Detroit Pistons visited the Philadelphia 76ers back in April 2024 and were 15-point underdogs. In 2026, it’s the Pistons who are the 15-point chalk.
Now, that’s a big number for a Detroit team that hasn’t covered much lately, but with all of Philly’s injuries, my 76ers vs. Pistons predictions have found some value in a player prop.
That and more NBA picks for this Eastern Conference clash set to tip off at 7 pm ET at Little Caesars Arena in Detroit on Thursday, March 12.
76ers vs Pistons prediction
76ers vs Pistons best bet: Tobias Harris Over 5.5 Rebounds (+102)
The Philadelphia 76ers were always going to be underdogs in this matchup, but all the injuries are why the number is so big.
Tyrese Maxey, Joel Embiid, and Kelly Oubre Jr. are all out. And more recently, Andre Drummond has been downgraded to questionable.
Philly already struggled on the glass, ranking 22nd in rebounding rate and 19th in opponent rebounds per game. The Detroit Pistons have the third-highest rebounding rate in the NBA.
So, give me Tobias Harris Over 5.5 rebounds. He’s hauling down 6.5 rebounds per game over his last 12, topping this number seven times.
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76ers vs Pistons same-game parlay
With all those injuries, somebody's going to have to score for the Sixers. My best bet in this case is Cam Payne. The journeyman guard showed he can still get buckets after coming off a 32-point performance against the Memphis Grizzlies.
With not many other options to take shots, over 12.5 points looks like a solid bet here.
However, that doesn’t mean Philly will score consistently. The Pistons are one of the best defensive teams in the NBA, ranking second in defensive rating. They’ll keep the Sixers under their team total in this one.
76ers vs Pistons SGP
- Tobias Harris Over 5.5 rebounds
- Cameron Payne Over 12.5 points
- 76ers TT Under 103.5
Our "from downtown" SGP: Bad Boys on the Boards
Just carrying on the theme that the Sixers will be bullied on the boards tonight. Isaiah Stewart has snagged five or more boards in three of his previous five, while Cunningham has snared six or more rebounds in three of his last six contests.
76ers vs Pistons SGP
- Tobias Harris Over 5.5 rebounds
- Jalen Duren Over 10.5 rebounds
- Cade Cunningham Over 5.5 rebounds
- Isaiah Stewart Over 4.5 rebounds
76ers vs Pistons odds
- Spread: 76ers +15.5 (-110) | Pistons -15.5 (-110)
- Moneyline: 76ers +750 | Pistons -1200
- Over/Under: Over 221.5 (-110) | Under 221.5 (-110)
76ers vs Pistons betting trend to know
The Pistons have hit the Game Total Under in 25 of their last 40 games for +9.60 Units and a 22% ROI. Find more NBA betting trends for 76ers vs. Pistons.
How to watch 76ers vs Pistons
| Location | Little Caesars Arena, Detroit, MI |
| Date | Thursday, March 12, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | Prime Video |
76ers vs Pistons latest injuries
Not intended for use in MA.
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