MLB Spring Training Picks and Predictions for March 16: Stay Classy, San Diego

Jason Wilson - Betting Analyst at Covers.com
Jason Wilson • Betting Analyst 19+ years betting experience
Updated: Mar 16, 2026 , 12:52 PM ET • 4 min read

With the Giants missing their four or five best hitters, the Padres can pick up a win, even if Walker Buehler is shaky in his latest spring outing.

Jackson Merrill San Diego Padres MLB
Photo By - Reuters Connect. San Diego Padres center fielder Jackson Merrill (3) at bat in the first inning against the Seattle Mariners.

Opening Day is quickly approaching as the World Baseball Classic wraps up, and we're turning our attentions back toward spring training with three MLB picks on Monday, March 16.

I'm making three moneyline spring training predictions, highlighted by the San Diego Padres, as they face a San Francisco Giants lineup missing its best bats.

Spring Training predictions for March 16

Pick Odds
Angels LAA moneyline +105
Padres SD moneyline -125
Rockies CHC moneyline +100
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Pick #1: Angels moneyline

Los Angeles Angels right-hander George Klassen has looked electric this spring, posting a 2.25 ERA with nine strikeouts over eight innings of work as he pursues a rotation gig to open the regular season.

A strong outing against the Athletics would go a long way toward making that happen. The A's have some big boppers like Nick Kurtz, Shea Langeliers, and Tyler Soderstrom, but this is a lineup that also struck out 23% of the time (tied for 10th in MLB) last year.

The plus money on the Angels' moneyline offers enough value, especially with no starter yet announced for the A's, that I'll take the plunge.

Pick #2: Padres moneyline

I don't know if the Walker Buehler experiment will work out for the San Diego Padres, but they will keep trying in case they strike gold.

Initially, he seems like a good fade candidate against the San Francisco Giants, but that's before you notice that Rafael Devers, Matt Chapman, Willy Adames, and Heliot Ramos aren't in the starting lineup. 

While the Friars have neither Manny Machado nor Fernando Tatis Jr. active as they lick their wounds from the Dominican Republic's controversial World Baseball Classic ouster, Jackson Merrill and Xander Bogaerts are still taking reps.

Even if Giants SP Tyler Mahle has yet to surrender a run in spring (he has issued seven walks in six innings), I'll take the more complete offense this afternoon.

Pick #3: Cubs moneyline

I'm really high on Cleveland Guardians starting pitcher Gavin Williams this season, but with Jose Ramirez nursing a banged-up shoulder, the offense will likely be without its best weapon against the Chicago Cubs.

Cade Horton hasn't had great results this spring, but he showed that he can hang at the big-league level in his 2025 rookie campaign, boasting a 2.67 ERA over 118 innings.

Lineups haven't been announced, but the edge there should typically favor Chicago. Doubly so with Ramirez on the bench or otherwise limited due to injury.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jason Wilson Covers.com
Betting Analyst

Jason Wilson is an experienced journalist who has worked in a variety of roles within the industry for the past 18 years. Working at community newspapers in New Brunswick, Jason wore many hats as a reporter, editor, and photographer, covering everything from sports to courts to municipal politics. After shifting gears and working as an educator for a few years in the 2010s, Jason returned to full-time work in media as an MLB news editor for six years at theScore in Toronto before joining Covers in late 2021.

He has honed his editorial acumen over his years in the industry, showcasing flexibility, patience, and a strong work ethic. While he was relatively new to sports betting upon joining Covers, Jason has taken the plunge with gusto to learn the ins and outs of the industry, both as a method to improve professionally and to add an extra angle to his sports fandom.

In addition to sports, Jason is an avid film nut and former movie critic who monitors the Academy Awards betting odds for Covers. Jason holds a Bachelor of Arts in journalism degree and a Bachelor of Education degree from St. Thomas University.

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