Reds vs Brewers Picks and Predictions: Will Castillo be the Difference?

Milwaukee's lead in the NL Central may be too much to overcome, but Cincinnati isn't going to roll over with a wild card berth to protect. Luis Castillo has handled tonight's opponent this season — find out if our Reds vs. Brewers picks side with the dogs

Last Updated: Aug 25, 2021 11:47 AM ET
Luis Castillo MLB Cincinnati Reds
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On Wednesday, August 25, the Milwaukee Brewers try to take back-to-back games from the Cincinnati Reds when the two meet for MLB betting action at American Family Field in Milwaukee, Wisconsin at 8:07 p.m. ET. 

Will Cincinnati find a way to even this series up? Keep reading our Reds vs. Brewers picks and predictions to find out. 

Reds vs Brewers game info

Location: American Family Field, Milwaukee, WI
Date: Wednesday, August 25, 2021
Time: 8:10 p.m. ET

Reds vs Brewers odds

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Starting pitchers

Luis Castillo (7-12, 4.35 ERA): Castillo is coming off an extremely impressive outing against the Miami Marlins, as the righty struck out seven batters in seven innings of one-run ball on August 19. Now, the 28-year-old gets to take on the Brewers, who he is 0-2 against this season. However, he does have a 2.79 ERA in five starts against Milwaukee this year, so the win-loss record isn’t reflective of the way he has pitched against this opponent. 

Brandon Woodruff (7-7, 2.48 ERA): Woodruff just might be coming off his worst start of the year, as the righty gave up six runs on eight hits in just five innings of work against the St. Louis Cardinals on August 19. However, Woodruff has been excellent against the Reds this season, as he has given up just two earned runs over 11.2 innings against Cincinnati. The Brewers will be hoping he can bounce back from his last start and handle the Reds here. 


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Reds: Jesse Winker (out), OF Nick Senzel (out)
Brewers: SS Willy Adames (out), SS Eduardo Escobar (out), OF Tyrone Taylor (out)
Find our latest MLB injury reports.

Betting trend to know

The Reds are 7-1 in their last eight games with a total between 7.0 and 8.5. Find more MLB betting trends for Reds vs. Brewers.

Moneyline pick

Castillo still hasn’t earned a victory over the Brewers this year, but that’s bound to change tonight. In two trips to Milwaukee this season, the righty has allowed just one run over 12.1 innings of work, and he struck out 13 batters over those games. Overall, the 28-year-old has been dominant against the Brewers this season, but his teammates haven’t been able to provide him with the run support he needs. Look for that to change tonight. 

While Woodruff has been great all year for Milwaukee, the 28-year-old is coming off a really rough showing against the Cardinals. Now, he runs into a team that had been really playing well before losing to Corbin Burnes on Tuesday — something that can happen to any team in the league, as Burnes is nearly unhittable.

Woodruff has struggled against some of these guys in the past, as Cincinnati is batting a combined .260 with four homers and 12 RBIs against the righty. Joey Votto, who has been the hottest player in baseball over the last month, has two homers off Woodruff in his career, and nobody on the planet would be surprised if he puts another one into the seats here. 

Overall, this value is just impossible to pass up with Castillo on the hill.

PREDICTION: Reds ML (+146) 

Over/Under pick

The Reds are sending one of their best pitchers to the mound in this game, and he has had all the success in the world against this Brewers lineup this year. With that, it’s quite easy to rely on him doing more of the same in this one. 

And while some of these Cincinnati hitters have gotten to Woodruff before, that doesn’t mean the Reds will be putting a big number on the scoreboard in this game. In fact, all it should take with Castillo on the mound is three or four runs to win this game, making the Under the right move. 

PREDICTION: Under 7.5 (-115) 

Reds vs Brewers betting card

  • Reds ML (+146)
  • Under 7.5 (-115) 

Picks made on 8/25/2021 at 11:30 a.m. ET

MLB parlays

Did you know that if you parlayed today’s MLB Reds vs. Brewers picks, you could win $35.99 on a $10 bet?

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