MLB Predictions and Moneyline Picks for Sunday, June 21

Phil Naessens - Contributor at Covers.com
Phil Naessens • Betting Analyst 19+ years betting experience
Updated: Jun 21, 2026 , 08:00 AM ET • 4 min read

MLB expert Phil Naessens has a moneyline prediction for all 15 Sunday MLB games!

Philadelphia Phillies Zack Wheeler MLB
Photo By - Reuters Connect. Zack Wheeler of the Philadelphia Phillies MLB

The end of another busy MLB week is here, and we have a robust, 15-game MLB Sunday slate to consider.

There is always value in the prediction markets, and I've scoured the board to find the most value for all 15 games. 

Read on for my Sunday MLB moneyline predictions and MLB picks for June 21. 

MLB moneyline picks for June 21

Matchup Pick
Reds Reds
vs
Yankees Yankees
Yankees
-138
Brewers Brewers
vs
Braves Braves
Brewers
+122
Nationals Nationals
vs
Rays Rays
Rays
-122
White Sox White Sox
vs
Tigers Tigers
Tigers
-127
Giants Giants
vs
Royals Marlins
Marlins
+108
Cardinals Cardinals
vs
Marlins Royals
Cardinals
-100
Guardians Guardians
vs
Astros Astros
Astros
-122
Blue Jays Blue Jays
vs
Cubs Cubs
Cubs
-100
Padres Padres
vs
Rangers Rangers
Rangers
-138
Pirates Pirates
vs
Rockies Rockies
Pirates
-133
Twins Twins
vs
Diamondbacks Diamondbacks
Twins
+156
Angels Angels
vs
Athletics Athletics
Athletics
-133
Orioles Orioles
vs
Dodgers Dodgers
Orioles
+233
Red Sox Red Sox
vs
Mariners Mariners
Red Sox
+127
Mets Mets
vs
Phillies Phillies
Phillies
-150

Prices courtesy of Polymarket as of 6-21.

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Expert MLB moneyline picks for June 21

Reds vs Yankees: Yankees (-138)

Yankees win probability: 58%

The Yankees are absolute money right now, hammering the ball to a top-3 ranking over the last two weeks with a 144 wRC+. Cincinnati is frozen at the plate with a cold 86 wRC+, and their tired relievers are handing out free passes at a 4.47 BB/9 clip. Back Gerrit Cole and the Yankees to dominate at home.

Brewers vs Braves: Brewers (+122)

Brewers win probability: 45%

We are catching solid plus-money value on a mismatch. Atlanta has completely bottomed out offensively, sitting dead last in baseball over the past 14 days with a miserable 74 wRC+. Milwaukee is swinging a red-hot stick at 144 wRC+, meaning they'll knock Bryce Elder out early and cash this ticket.

Nationals vs Rays: Rays (-122)

Rays win probability: 55%

Lock in the Rays at a short price before this line moves. Washington's bullpen is a flat-out disaster right now, failing to miss bats with a bottom-tier 5.31 K/9 over the last two weeks. Tampa Bay's solid bullpen counters at a sharp 9.36 K/9, giving them the weapon needed to lock down the late innings.

White Sox vs Tigers: Tigers (-127)

Tigers win probability: 55.9%

Detroit owns the night. While the offenses are close, Detroit’s 102 wRC+ slightly edges Chicago's 99; the Tigers boast a brilliant, lockdown 1.93 ERA out of the bullpen over the past 14 days. Chicago's relief unit is highly vulnerable, coughing up hard contact at a 4.96 xERA.

Giants vs Marlins: Marlins (+108)

Marlins win probability: 48.1%

Do not miss the boat on this home underdog. Miami holds the better offense right now (115 vs. 110 wRC+) and pairs it with the single most dominant bullpen in baseball over the last 14 days, pitching to a pristine 2.40 ERA and an electric 10.91 K/9. The Marlins are the easiest prediction on the board.

Cardinals vs Royals: Cardinals (-100)

Cardinals win probability: 50%

At a flat pick'em price, the edge goes directly to St. Louis. The Cardinals feature a highly functional, top-10 offense over the last two weeks with a 124 wRC+. Kansas City's bullpen is a ticking time bomb, surrendering a heavy 4.80 BB/9 and a dangerous 5.51 xFIP. Take the better bats.

Guardians vs Astros: Astros (-122)

Astros win probability: 55%

Houston is probably the safest prediction on the afternoon slate. Cleveland’s hitters are completely lost, averaging a bottom-three 80 wRC+ over the last 14 days. They don't stand much of a chance of mounting a late comeback against an elite Astros bullpen that is sporting a stellar 2.11 ERA and a 3.25 FIP over the past two weeks. 

Blue Jays vs Cubs: Cubs (-100)

Cubs win probability: 50%

We get the Cubs at even money at Wrigley Field. Chicago's bats are completely outclassing Toronto right now, checking in with an elite 127 wRC+ compared to the Blue Jays' mediocre 108 wRC+. Expect Shota Imanaga to get plenty of run support to secure an easy win.

Padres vs Rangers: Rangers (-138)

Rangers win probability: 58%

Lay the short price on Texas with supreme confidence. The Padres' offense has run completely dry over the past two weeks, plunging down to a sub-par 92 wRC+. Texas brings a far steadier, above-average 112 wRC+ lineup to the plate to crack Lucas Giolito early and often.

Pirates vs Rockies: Pirates (-133)

Pirates win probability: 57.1%

This is a classic "bet against Coors Field catastrophe" spot. Colorado features the absolute worst bullpen in the majors over the last 14 days, bleeding runs to a 5.55 ERA and walking everyone with a 5.36 BB/9. Pittsburgh’s hot 112 wRC+ bats will blow this open late.

Twins vs Diamondbacks: Twins (+156)

Twins win probability: 39.1%

The markets have made a massive mathematical mistake here. Arizona's offense is anemic, sitting near the bottom tier at an 89 wRC+. Minnesota is a top-4 club over the same stretch, hammering the ball to a 133 wRC+. Grab the heavy plus-money on the superior team.

Angels vs A's: Athletics (-133)

Athletics win probability: 57.1%

Ride the hottest team in baseball. The Athletics offense has morphed into a terrifying monster, ranking 1st in the majors over the last 14 days with an elite 147 wRC+ and a massive .275 ISO. They are going to obliterate Reid Detmers and out-slug the Angels this afternoon.

Orioles vs Dodgers: Orioles (+233)

Orioles win probability: 30%

We are passing on the heavily inflated juice to grab a massive plus-money payout on the Orioles. Brandon Young matches up against Emmet Sheehan here, giving us a distinct starting edge to exploit. Back the massive underdog while avoiding the highly restrictive -245 vig.

Red Sox vs Mariners: Red Sox (+127)

Red Sox win probability: 44.1%

This is the ultimate late-inning ambush play. Logan Gilbert is tough, but Seattle’s bullpen has completely imploded over the last 14 days, putting up a disastrous 6.03 ERA and an uncontrollable 5.54 BB/9. Boston's bats can steal this one on the road.

Mets vs Phillies: Phillies (-150)

Phillies win probability: 60%

Zack Wheeler is on the mound at home, and he’s backed by a massive late-inning pitching advantage. Over the last two weeks, Philadelphia’s relief core has been locked in with a sharp 3.58 FIP. They will easily outclass a Mets bullpen that is actively bleeding runs with an ugly 4.23 FIP.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Phil Naessens
Betting Analyst

Prior to joining Covers in 2022, Phil Naessens spent 38 years as a resident tennis pro in Las Vegas, Mykonos, and Corfu, Greece. He’s the past host of the Phil Naessens Show (Armed Forces Radio), and currently hosts the Crush and Rush Tennis Podcast.

Phil is the author of the Betting 101 series (MLB, NFL, NCAAF, and Tennis) and has written for numerous publications, including Advance Local, SB Nation, FanSided, and Lenny Melnick Fantasy Sports. 

His favorite sports to bet on are tennis, MLB, WNBA, Euro men’s and women’s hoops, NCAA sports, NFL, and the NBA. Phil has numerous betting accounts in the US and Europe, and his best advice is to line shop for the best value possible.

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