The San Diego Padres host the San Francisco Giants in the opening matchup of this four-game series at PETCO Park. MLB odds list San Diego as a -145 favorite, while the total sits at 7.5.
My Giants vs. Padres predictions believe Robbie Ray will be at his best in this NL West matchup.
Read on for my MLB picks for Monday, August 18.
Giants vs Padres prediction
Giants vs Padres best bet: Robbie Ray Over 5.5 strikeouts (+115)
The San Francisco Giants hand the ball to left-hander Robbie Ray, who should serve as a good candidate to back. Through 25 starts this season, Ray is 9-6 with a 2.98 ERA and 1.14 WHIP.
His underlying metrics are equally strong. Entering this matchup, the southpaw ranks in the 71st percentile in xERA, and 78th percentile in xBA.
Ray has particularly thrived in generating swings-and-misses. He ranks in the 71st percentile in whiff rate, 52nd percentile in chase rate, and 71st percentile in strikeout rate.
Subsequently, he has recorded six or more strikeouts in two of his past three starts. Ray boasts a 3.32 ERA and 1.11 WHIP over that stretch.
This success is likely to continue against the San Diego Padres. Ray struck out at least six batters in 13 of his last 17 outings against this opponent.
Giants vs Padres same-game parlay (SGP)
Another strong start from Ray increases San Francisco’s probability of winning, but the Giants still need to score some runs. Enter Rafael Devers, who boasts a .571 SLG and .476 xSLG through 24 plate appearances against San Diego’s Nestor Cortes.
Devers also enters this contest in good form, posting a .551 SLG and .948 OPS over his past 13 games.
Giants vs Padres odds
- Moneyline: San Francisco +122 | San Diego -145
- Run line: San Francisco +1.5 | San Diego -1.5
- Over/Under: Over 7.5 | Under 7.5
Giants vs Padres trend
Ray has recorded six or more strikeouts in six of his past 10 starts. Find more MLB betting trends for Giants vs. Padres.
How to watch Giants vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Monday, August 18, 2025 |
| First pitch | 9:40 p.m. ET |
| TV | NBC Sports Bay Area, SDPA |
| Giants starting pitcher | Robbie Ray (9-6, 2.98 ERA) |
| Padres starting pitcher | Nestor Cortes (1-1, 5.71 ERA) |
Giants vs Padres latest injuries
Giants vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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