Cubs vs Astros Prediction, Picks & Odds for Today’s MLB Game

The Astros are cooking right now, and the Cubbies don't have the means to slow them down tonight.

Tom Oldfield - Contributor at Covers.com
Tom Oldfield • Betting Analyst
Jun 28, 2025 • 11:35 ET • 4 min read
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This article contains predictions for an old game!

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Jake Meyers Houston Astros MLB
Photo By - Imagn Images. Houston Astros center fielder Jake Meyers (6) reacts after crossing home plate to score the winning run

Division leaders collide again at Daikin Park tonight as the Houston Astros put their five-game win streak on the line against the Chicago Cubs.

Houston powered to a 7-4 victory last night, sparked by three-run homers from Cam Smith and Yainer Diaz, and my Cubs vs Astros predictions signal more home cooking here in a prime-time slot.

Read on for my free MLB picks and betting angles ahead of this marquee June 28 battle.

Cubs vs Astros prediction

My Cubs vs Astros best bet: Astros moneyline (-115 at bet365)

Cubs vs Astros same-game parlay (SGP)

Astros moneyline

Over 8.5

Jake Meyers Over 1.5 total bases

Cubs vs Astros odds

Cubs vs Astros live odds

Cubs vs Astros opening odds

  • Moneyline: Chicago +105 | Houston -125
  • Run line: Chicago +1.5 (-210) | Houston -1.5 (+175)
  • Over/Under: Over 8.5 (-125) | Under 8.5 (+105)

Cubs vs Astros trend

The Over is 7-2 in Chicago’s last nine contests. Find more MLB betting trends for Cubs vs. Astros.

How to watch Cubs vs Astros and game info

Location Daikin Park, Houston, TX
Date Saturday, 6-28-2025
First pitch 7:15 p.m. ET
TV FOX
Cubs starting pitcher Colin Rea
(4-3, 4.42 ERA)
Astros starting pitcher Lance McCullers Jr.
(1-2, 4.91 ERA)

Cubs vs Astros latest injuries

Cubs vs Astros weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Tom Oldfield - Covers
Betting Analyst

Tom Oldfield’s sports writing journey over the past 20 years has taken him from the Premier League and Champions League to the NFL, NBA, WNBA and MLB, with a wide range of articles and betting previews. Tom has worked closely with London’s Sportsbeat sports news agency as well as (thrillingly!) covering the Toronto Raptors’ 2019 NBA championship run, and he has appeared on BBC World Service and The Back Page podcast.

A graduate of the University of Nottingham in the UK, he is the author of biographies on Cristiano Ronaldo, Rafael Nadal, Gary Neville and Cesc Fabregas, and he co-authors a long-running series of children’s soccer books with his brother, Matt.

As a regular bettor across the top sports leagues, particularly with FanDuel and bet365, he is well versed on all the major markets and the next big game is rarely far from his thoughts. The best betting advice he has received is to monitor multiple sportsbooks to grab the best possible value.

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