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    All Forums | Politics

    DJT n MUSK are destrying the USA

    «First Previous 1234 Next Last»
    fubah2
    THEMUGG
    kcblitzkrieg
    Europa
    KellyM_1964
    ...
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    Views: 1431
    Posts: 88
    «First Previous 1234 Next Last»
     
    fubah2
    fubah2
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    Posted: Apr. 2, 2025 - 1:59 AM ET #51

    an_speak HEADLINES Tuesday . . .

     

     

    Liberals defeat Musk, trump

     

    CNN —

    Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term.

    Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.

                                  an_happydude

    Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.

                                   an_cheers

    Reply

    an_speak HEADLINES Tuesday . . .

     

     

    Liberals defeat Musk, trump

     

    CNN —

    Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term.

    Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.

                                  an_happydude

    Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.

                                   an_cheers

     
    THEMUGG
    THEMUGG
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    Posted: Apr. 2, 2025 - 4:39 AM ET #52

     an_roll_laugh

    Reply

     an_roll_laugh

     
    kcblitzkrieg
    kcblitzkrieg
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    Posted: Apr. 2, 2025 - 9:51 AM ET #53

    @THEMUGG

     What's funny?  

     With this state supreme court win Wisconsin will be able to redistrict their congressional map and pick up House seats.....Dems winning the House = another impeachment.  

     Fun times.  

    Time is a flat circle....
    Reply

    @THEMUGG

     What's funny?  

     With this state supreme court win Wisconsin will be able to redistrict their congressional map and pick up House seats.....Dems winning the House = another impeachment.  

     Fun times.  

     
    Europa
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    Posted: Apr. 2, 2025 - 11:15 AM ET #54

    Quote Originally Posted by fubah2:

    HEADLINES Tuesday . . .     Liberals defeat Musk, trump   CNN — Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term. Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.                               Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.

    Money isn't working at every time or on everything. Last night, majority of Wisconsin voters casted the rejection of Musk and plutocracy.   

     

     

    Reply

    Quote Originally Posted by fubah2:

    HEADLINES Tuesday . . .     Liberals defeat Musk, trump   CNN — Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term. Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.                               Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.

    Money isn't working at every time or on everything. Last night, majority of Wisconsin voters casted the rejection of Musk and plutocracy.   

     

     

     
    KellyM_1964
    KellyM_1964
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    Posted: Apr. 2, 2025 - 3:43 PM ET #55

    Quote Originally Posted by fubah2:

    HEADLINES Tuesday . . .

     

    Liberals defeat Musk, trump

     

    CNN —

    Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term.

    Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.

                                  an_happydude

    Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.                             

    @fubah2

    convincing victory  !!

    crawford   55%  an_2drinks

    schimel  45%

     

     

    "I'm the MOST HONEST human being that GOD EVER created!" - Donald "the felon" Trump
    Reply

    Quote Originally Posted by fubah2:

    HEADLINES Tuesday . . .

     

    Liberals defeat Musk, trump

     

    CNN —

    Democratic-backed candidate Susan Crawford wins Wisconsin’s Supreme Court race, maintaining the liberal majority on the court in a key battleground state less than three months into [the convicted felon’s] second term.

    Crawford, a liberal circuit court judge in Dane County, beat the conservative candidate Brad Schimel, a Waukesha County judge who received Trump’s backing in the final stretch of the campaign. The race was officially nonpartisan, but Crawford’s victory will be seen as a bright spot for Democrats in Wisconsin and nationwide as voters handed the president’s preferred candidate a defeat in the first major political test of the second Trump era.

                                  an_happydude

    Crawford and her Democratic allies also worked to turn the election into a referendum on Trump accomplice,  Elon Musk, who poured millions of his personal fortune into the race. It quickly became the most expensive judicial contest in US history.                             

    @fubah2

    convincing victory  !!

    crawford   55%  an_2drinks

    schimel  45%

     

     

     
    fubah2
    fubah2
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    Posted: Apr. 3, 2025 - 5:15 PM ET #56

    an_speak US oil prices plunge by the most in nearly 3 yrs

     

    Reply

    an_speak US oil prices plunge by the most in nearly 3 yrs

     

     
    Zeus4par
    Zeus4par
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    Posted: Apr. 3, 2025 - 7:21 PM ET #57

    Quote Originally Posted by KellyM_1964:

       @fubah2

    convincing victory  !!

    crawford   55%  

    schimel  45%

     

    win

    Schimel was endorsed by Trump and backed by Musk with over $20 million

    Reply

    Quote Originally Posted by KellyM_1964:

       @fubah2

    convincing victory  !!

    crawford   55%  

    schimel  45%

     

    win

    Schimel was endorsed by Trump and backed by Musk with over $20 million

     
    fubah2
    fubah2
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    Posted: Apr. 4, 2025 - 1:39 AM ET #58


    " Trump's tariffs announcement was full-on crazy.
    He's justifying them with COMPLETELY FALSE claims about other countries' tariffs. I don't know where his numbers are coming from but they have nothing to do with reality! It's a really BAD day for the U.S. economy."


                                              - Paul Krugman, Nobel prize-winning economist

    Reply


    " Trump's tariffs announcement was full-on crazy.
    He's justifying them with COMPLETELY FALSE claims about other countries' tariffs. I don't know where his numbers are coming from but they have nothing to do with reality! It's a really BAD day for the U.S. economy."


                                              - Paul Krugman, Nobel prize-winning economist

     
    thirdperson
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    Posted: Apr. 4, 2025 - 4:17 AM ET #59

    After liberation day, stock markets post worst day since 2020 in reaction to Trump tariffs.  US dollar lost all gains since his re-election. Republican Pence calls Trump tariffs the biggest tax hike in US history. Economist Beckworth says, "this has to be one of the biggest unforced economic errors in US history." 

    Reply

    After liberation day, stock markets post worst day since 2020 in reaction to Trump tariffs.  US dollar lost all gains since his re-election. Republican Pence calls Trump tariffs the biggest tax hike in US history. Economist Beckworth says, "this has to be one of the biggest unforced economic errors in US history." 

     
    cd329
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    Posted: Apr. 4, 2025 - 5:59 PM ET #60

    South african scumbag muskrat who has committed election fraud and should be in jail and then deported is now claiming the wisconsin supreme court race was rigged, lolllllllllllllllllll.  He is mad because the people of wisconsin wouldnt let this scumbag buy the election with his money or his he mad that he had his hacker team busy working on fleecing our govt systems?  This bullshit with republicans is getting real old now.  Every time they lose an election, they claim they only lost because the election was rigged.  Why do these assholes believe that they cant lose an election?  Should we just get rid of all elections and declare republican candidates the winners? Oh wait, isnt trumpy trying to do that already lollllllllllll.

    Enough of this bullshit republicans.

     

    Reply

    South african scumbag muskrat who has committed election fraud and should be in jail and then deported is now claiming the wisconsin supreme court race was rigged, lolllllllllllllllllll.  He is mad because the people of wisconsin wouldnt let this scumbag buy the election with his money or his he mad that he had his hacker team busy working on fleecing our govt systems?  This bullshit with republicans is getting real old now.  Every time they lose an election, they claim they only lost because the election was rigged.  Why do these assholes believe that they cant lose an election?  Should we just get rid of all elections and declare republican candidates the winners? Oh wait, isnt trumpy trying to do that already lollllllllllll.

    Enough of this bullshit republicans.

     

     
    fubah2
    fubah2
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    Posted: Apr. 4, 2025 - 6:14 PM ET #61

    Quote Originally Posted by thirdperson:

    After liberation day, stock markets post worst day since 2020 in reaction to Trump tariffs.  US dollar lost all gains since his re-election. Republican Pence calls Trump tariffs the biggest tax hike in US history. Economist Beckworth says, "this has to be one of the biggest unforced economic errors in US history."

    I can't wait to review and post what the polls say when they come out next week!

                                                               an_popcorn

    Reply

    Quote Originally Posted by thirdperson:

    After liberation day, stock markets post worst day since 2020 in reaction to Trump tariffs.  US dollar lost all gains since his re-election. Republican Pence calls Trump tariffs the biggest tax hike in US history. Economist Beckworth says, "this has to be one of the biggest unforced economic errors in US history."

    I can't wait to review and post what the polls say when they come out next week!

                                                               an_popcorn

     
    thirdperson
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    Posted: Apr. 6, 2025 - 5:12 AM ET #62

    Tax debacle shows why failing democracy is so dangerous. If checks and balances are working, Trump shouldn't be able to impose tariffs to threaten global economy.  Under US constitution, congress has sole authority to raise taxes.  Not the president.  Now Trump is a mad king who makes decisions out of touch with reality.  Without constraints, there is higher risk of bad policies being implemented. 

    Reply

    Tax debacle shows why failing democracy is so dangerous. If checks and balances are working, Trump shouldn't be able to impose tariffs to threaten global economy.  Under US constitution, congress has sole authority to raise taxes.  Not the president.  Now Trump is a mad king who makes decisions out of touch with reality.  Without constraints, there is higher risk of bad policies being implemented. 

     
    JEG53
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    Posted: Apr. 6, 2025 - 7:20 AM ET #63

    @thirdperson

     One big problem is the Senate and Congress not doing their jobs and allowing these Dummies to threaten them and they just cower with this POS. The Senate just confirmed a BAD TALK SHOW HOST to lead Medicare and Medicaid, another idiot the Senate rolls over for trump.

    Reply

    @thirdperson

     One big problem is the Senate and Congress not doing their jobs and allowing these Dummies to threaten them and they just cower with this POS. The Senate just confirmed a BAD TALK SHOW HOST to lead Medicare and Medicaid, another idiot the Senate rolls over for trump.

     
    cd329
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    Posted: Apr. 7, 2025 - 11:05 PM ET #64

    an_clapbravo to musk and his computer goon squad.  online system has been crashing everyday, people are getting letters their benefits have been stopped.  trumpy and musk arent getting rid of social security, they are destroying it so it doesnt work and it will basically shut its self down.  Hey magas dont care cause they are all wealthy and its only those damn democrats collecting social securityan_brick

    Reply

    an_clapbravo to musk and his computer goon squad.  online system has been crashing everyday, people are getting letters their benefits have been stopped.  trumpy and musk arent getting rid of social security, they are destroying it so it doesnt work and it will basically shut its self down.  Hey magas dont care cause they are all wealthy and its only those damn democrats collecting social securityan_brick

     
    cd329
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    Posted: Apr. 8, 2025 - 1:46 AM ET #65

    https://www.yahoo.com/news/doge-goons-cause-major-crash-174014137.html

    Reply

    https://www.yahoo.com/news/doge-goons-cause-major-crash-174014137.html

     
    cd329
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    Posted: Apr. 8, 2025 - 10:45 PM ET #66

    Heres the question everybody should be asking muskrat and nobody is, which is pretty damn sad.

    Is muskrat gonna move all his factories to the USA to MAKE AMERICA GREAT AGAIN and give lots of workers good paying jobs?

    Or is trumpy just picking and choosing which companies need to move back here and give muskrat a pass on this.

    Thought true leaders are supposed to lead by example.  Trumpy should be telling muskrat he needs to move his production back here. 

    Isnt that fair magas or do you magas want to also give him a free pass?

    Reply

    Heres the question everybody should be asking muskrat and nobody is, which is pretty damn sad.

    Is muskrat gonna move all his factories to the USA to MAKE AMERICA GREAT AGAIN and give lots of workers good paying jobs?

    Or is trumpy just picking and choosing which companies need to move back here and give muskrat a pass on this.

    Thought true leaders are supposed to lead by example.  Trumpy should be telling muskrat he needs to move his production back here. 

    Isnt that fair magas or do you magas want to also give him a free pass?

     
    cd329
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    Posted: Apr. 9, 2025 - 10:44 AM ET #67

    Amazing not 1 maga here has come out and said of course muskrat should have to bring his production to the USA, not 1 maga.  Its like when they get confronted with facts, they vanish cause it doesnt fit their narrative.

    Reply

    Amazing not 1 maga here has come out and said of course muskrat should have to bring his production to the USA, not 1 maga.  Its like when they get confronted with facts, they vanish cause it doesnt fit their narrative.

     
    thirdperson
    thirdperson
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    Participation Meter
    Joined: Feb, 2005
    Posts: 9493
    Posted: Apr. 9, 2025 - 12:14 PM ET #68

    Even if tariffs are permanent, Musk is likely to keep Tesla factories overseas to serve international market. To be competitive, automakers need to take advantage of production in Canada and Mexico. Without advantages, most American. cars would be sold in the U.S. but fewer in other countries.  

    Reply

    Even if tariffs are permanent, Musk is likely to keep Tesla factories overseas to serve international market. To be competitive, automakers need to take advantage of production in Canada and Mexico. Without advantages, most American. cars would be sold in the U.S. but fewer in other countries.  

     
    spockgato
    spockgato
    Banned
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    Posts: 15326
    Posted: Apr. 9, 2025 - 1:20 PM ET #69

    Third poppin’ whistles on the honestness tip hot doggin’ it with the missile……

    That’s lyrically worded , to be interpreted , as something more earnest than Jim Varney

    Or his horrible carnival artistry , marvelous , magnifique , 

    What you said about foreign cars , auto parts , and why they harbor overseas peace_5

    I agree with my whole heart and not just a sliver or a small section of it . Kudos an_clap

    wallstreetcappers craps in his draws and pees fuckin backwards from his vaj with a squirt.
    Reply

    Third poppin’ whistles on the honestness tip hot doggin’ it with the missile……

    That’s lyrically worded , to be interpreted , as something more earnest than Jim Varney

    Or his horrible carnival artistry , marvelous , magnifique , 

    What you said about foreign cars , auto parts , and why they harbor overseas peace_5

    I agree with my whole heart and not just a sliver or a small section of it . Kudos an_clap

     
    cd329
    cd329
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    Joined: Mar, 2004
    Posts: 23797
    Posted: Apr. 9, 2025 - 1:57 PM ET #70

    Quote Originally Posted by thirdperson:

    Even if tariffs are permanent, Musk is likely to keep Tesla factories overseas to serve international market. To be competitive, automakers need to take advantage of production in Canada and Mexico. Without advantages, most American. cars would be sold in the U.S. but fewer in other countries.

    so why shouldnt he be forced to move some factories back here the same way trumpy is trying to do with all the other companies?  He gets a free pass. If trumpy wants companies here, then it should be every company, zero exceptions.  Just my opinion, which means nothing

    Reply

    Quote Originally Posted by thirdperson:

    Even if tariffs are permanent, Musk is likely to keep Tesla factories overseas to serve international market. To be competitive, automakers need to take advantage of production in Canada and Mexico. Without advantages, most American. cars would be sold in the U.S. but fewer in other countries.

    so why shouldnt he be forced to move some factories back here the same way trumpy is trying to do with all the other companies?  He gets a free pass. If trumpy wants companies here, then it should be every company, zero exceptions.  Just my opinion, which means nothing

     
    fubah2
    fubah2
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    Joined: Aug, 2012
    Posts: 54105
    Posted: Apr. 10, 2025 - 7:56 PM ET #71

    Direction of our economy?

     

    CNN -
    Economists said trump's economic damage was done,
    and many say there is still an elevated risk of a US and
    global recession.

    an_lightStocks are still well below where they were before Trump
    unveiled his “Liberation Day” tariffs last week, and those
    large stock market losses, existing tariffs and high degree
    of uncertainty about American trade policy are enough
    to sink the economy, they say.

    Reply

    Direction of our economy?

     

    CNN -
    Economists said trump's economic damage was done,
    and many say there is still an elevated risk of a US and
    global recession.

    an_lightStocks are still well below where they were before Trump
    unveiled his “Liberation Day” tariffs last week, and those
    large stock market losses, existing tariffs and high degree
    of uncertainty about American trade policy are enough
    to sink the economy, they say.

     
    fubah2
    fubah2
    Legend
    Participation Meter
    Joined: Aug, 2012
    Posts: 54105
    Posted: Apr. 14, 2025 - 9:15 PM ET #72


    an_speak Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!

     

    The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

    Reply


    an_speak Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!

     

    The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

     
    KellyM_1964
    KellyM_1964
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    Joined: May, 2009
    Posts: 16793
    Posted: Apr. 20, 2025 - 10:42 AM ET #73

    Quote Originally Posted by fubah2:

    Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!   The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

    about time someone showed some backbone

     

     

    "I'm the MOST HONEST human being that GOD EVER created!" - Donald "the felon" Trump
    Reply

    Quote Originally Posted by fubah2:

    Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!   The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

    about time someone showed some backbone

     

     

     
    nature1970
    nature1970
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    Joined: Jan, 2015
    Posts: 21593
    Posted: Apr. 20, 2025 - 11:24 AM ET #74

    Quote Originally Posted by fubah2:

    Direction of our economy?   CNN - Economists said trump's economic damage was done, and many say there is still an elevated risk of a US and global recession. Stocks are still well below where they were before Trump unveiled his “Liberation Day” tariffs last week, and those large stock market losses, existing tariffs and high degree of uncertainty about American trade policy are enough to sink the economy, they say.

    Warning good news happy Easter....

    offtopic

    https://www.biorxiv.org/content/10.1101/2024.11.12.623261v1

    You wanna live forever. 

    ABSTRACT
    Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induced photoaging. Detrimental structural and physiological changes caused by aging include epidermal thinning due to stem cell depletion and dermal atrophy associated with decreased collagen production. Here, we present a comprehensive single-cell atlas of skin aging, analyzing samples from young, middle-aged, and elderly individuals, including both sun-exposed and sun-protected areas. This atlas reveals age-related cellular composition and function changes across various skin cell types, including epidermal stem cells, fibroblasts, hair follicles, and endothelial cells. Using our atlas, we have identified basal stem cells as a highly variable population across aging, more so than other skin cell populations such as fibroblasts. In basal stem cells, we identified ATF3 as a novel regulator of skin aging. ATF3 is a transcriptional factor for genes involved in the aging process, with its expression reduced by 20% during aging. Based on this discovery, we have developed an innovative mRNA-based treatment to mitigate the effects of skin aging. Cell senescence decreased 25% in skin cells treated with ATF3 mRNA, and we observed an over 20% increase in proliferation in treated basal stem cells. Importantly, we also found crosstalk between keratinocytes and fibroblasts as a critical component of therapeutic interventions, with ATF3 rescue of basal cells significantly enhancing fibroblast collagen production by approximately 200%. We conclude that ATF3-targeted mRNA treatment effectively reverses the effects of skin aging by modulating specific cellular mechanisms, offering a novel, targeted approach to human skin rejuvenation.

    Competing Interest Statement
    The authors have declared no competing interest.

    Reply

    Quote Originally Posted by fubah2:

    Direction of our economy?   CNN - Economists said trump's economic damage was done, and many say there is still an elevated risk of a US and global recession. Stocks are still well below where they were before Trump unveiled his “Liberation Day” tariffs last week, and those large stock market losses, existing tariffs and high degree of uncertainty about American trade policy are enough to sink the economy, they say.

    Warning good news happy Easter....

    offtopic

    https://www.biorxiv.org/content/10.1101/2024.11.12.623261v1

    You wanna live forever. 

    ABSTRACT
    Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induced photoaging. Detrimental structural and physiological changes caused by aging include epidermal thinning due to stem cell depletion and dermal atrophy associated with decreased collagen production. Here, we present a comprehensive single-cell atlas of skin aging, analyzing samples from young, middle-aged, and elderly individuals, including both sun-exposed and sun-protected areas. This atlas reveals age-related cellular composition and function changes across various skin cell types, including epidermal stem cells, fibroblasts, hair follicles, and endothelial cells. Using our atlas, we have identified basal stem cells as a highly variable population across aging, more so than other skin cell populations such as fibroblasts. In basal stem cells, we identified ATF3 as a novel regulator of skin aging. ATF3 is a transcriptional factor for genes involved in the aging process, with its expression reduced by 20% during aging. Based on this discovery, we have developed an innovative mRNA-based treatment to mitigate the effects of skin aging. Cell senescence decreased 25% in skin cells treated with ATF3 mRNA, and we observed an over 20% increase in proliferation in treated basal stem cells. Importantly, we also found crosstalk between keratinocytes and fibroblasts as a critical component of therapeutic interventions, with ATF3 rescue of basal cells significantly enhancing fibroblast collagen production by approximately 200%. We conclude that ATF3-targeted mRNA treatment effectively reverses the effects of skin aging by modulating specific cellular mechanisms, offering a novel, targeted approach to human skin rejuvenation.

    Competing Interest Statement
    The authors have declared no competing interest.

     
     
    fubah2
    fubah2
    Legend
    Participation Meter
    Joined: Aug, 2012
    Posts: 54105
    Posted: Apr. 20, 2025 - 9:55 PM ET #75

    Quote Originally Posted by KellyM_1964:

    Quote Originally Posted by fubah2: Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!   The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

     

     

     

    about time someone showed some backbone

    @KellyM_1964

     It seems the movement against MAGA authoritarianism is well underway among the American populace but more is needed among corp and lawmakers, as well as lawmakers and even foreign countries.

    Reply

    Quote Originally Posted by KellyM_1964:

    Quote Originally Posted by fubah2: Attorneys working at a law firm that just cut a gutless deal with [the rapist/convicted felon] are reportedly in open revolt!   The Bulwark's Sam Stein reports that more than 500 associate attorneys and staff at Allen Overy Shearman Sterling US LLP signed a letter imploring the firm not to take an offer from Trump to do pro bono work on behalf of his administration in exchange for him not revoking security clearances.

     

     

     

    about time someone showed some backbone

    @KellyM_1964

     It seems the movement against MAGA authoritarianism is well underway among the American populace but more is needed among corp and lawmakers, as well as lawmakers and even foreign countries.

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