Mayweather vs. Pacquiao 2 Odds: Mayweather Opens as Favorite

Trevor Knapp - Betting Analyst at Covers.com
Trevor Knapp • Betting Analyst 7+ years betting experience
Updated: May 8, 2026 , 02:54 PM ET • 4 min read

A rematch years in the making lands in Las Vegas and will stream globally on Netflix. Here’s an early look at Mayweather vs. Pacquiao 2 odds.

Manny Pacquiao against Floyd Mayweather during their boxing bout.
Photo By - Reuters Connect. Manny Pacquiao gainst Floyd Mayweather during their boxing bout.

The first fight broke records. The rematch will break the internet.

Floyd Mayweather and Manny Pacquiao have reportedly agreed to run it back in Las Vegas, streaming globally on Netflix.

The exact date has yet to be confirmed, but reports suggest the fight will take place on either September 25 or September 26 at either T-Mobile Arena or MGM Grand Garden Arena.

Sportsbooks have already released odds for the rematch, currently installing Mayweather as a -205 favorite over Pacquiao after early movement.

Mayweather vs Pacquiao odds

Fighter DraftKings
Floyd Mayweather Jr.  -205
Manny Pacquiao +160

Odds as of May 8. 

Mayweather opened as a -225 favorite following the initial release of markets. The line has since shortened to -205, suggesting early support for Pacquiao.

The move trims Mayweather’s implied win probability from roughly 69% to 67%, reflecting immediate two-way action as bettors weigh age, inactivity, and rematch dynamics.

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Breaking down the opening line

With the rematch confirmed as a sanctioned professional bout under standard rules, sportsbooks had a clear framework for pricing risk. Twelve three-minute rounds, official judges, approved gloves, and commission oversight reduce uncertainty and allow bookmakers to lean on traditional boxing models when setting a line.

That structure helps explain why Mayweather remains favored at -205 after opening higher. Oddsmakers can reference the first fight’s tactical pace and decision outcome rather than guessing how exhibition-style rules might introduce additional volatility.

The first fight blueprint

The pair's first fight on May 2, 2015, went 12 rounds, and Mayweather won a clear unanimous decision as a -240 favorite.

That fight drew a record 4.4 million pay-per-view buys and more than $600 million in revenue. Events of that scale attract massive betting handle, meaning sportsbooks should expect significant early action when lines open.

It wasn’t dramatic. It was controlled. Mayweather set the pace, defended well, and landed cleaner shots. Pacquiao had a few strong moments, but he couldn’t consistently break through.

The important part for bettors: it went the distance, and it was tactical, not violent.

With both fighters now approaching 50, the opening line of Mayweather being favored suggests sportsbooks expect a similar tactical script, favoring control and experience over volatility.

Pacquiao sitting at +160 creates a natural underdog draw, and early public action could test whether that number holds.

Current form and activity 

Floyd Mayweather officially retired in 2017 after beating Conor McGregor, but he’s stayed active through exhibitions and high-profile events. At 48, he’s still involved in the spotlight and is scheduled for another exhibition bout in April against Mike Tyson.

Manny Pacquiao retired in 2021 before returning to the ring last July, fighting Mario Barrios to a majority draw in a WBC welterweight title bout. He showed flashes of his old speed, but at 47, the pace isn’t what it once was. Pacquiao is also set for an April exhibition against Ruslan Provodnikov.

For bettors, the key question is timing. Both fighters are staying active, but neither has been in consistent, elite-level competition in recent years. That uncertainty is now reflected in a line that makes Mayweather a clear favorite, but not an overwhelming one.

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Trevor Knapp - Covers
Betting Analyst

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Indianapolis Colts and Toronto Blue Jays fan.

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